脑囊虫病患者细胞因子表达不平衡——系统性回顾及Meta分析（英文）  

Cytokines imbalance in patients with neurocysticercosis:a review and meta-analysis

作　　者：陈小华[1] 王非[1] 邹洋[1] 田小军[1] 谷俊朝[1] 

机构地区：[1]首都医科大学附属北京友谊医院,北京热带医学研究所,热带病防治研究北京市重点实验室,北京100050

出　　处：《中国人兽共患病学报》2016年第2期137-147,共11页Chinese Journal of Zoonoses

基　　金：国家自然科学基金青年科学基金项目(No.81101269);首都医科大学省部级重点实验室开放研究课题基金(No.2013RDBF04)联合资助

摘　　要：脑囊虫病可能导致患者中枢和外周免疫系统的功能障碍,然而,在个别研究中细胞因子表达特征的结果是相互矛盾的。本研究目的是系统地分析囊尾蚴感染状态下脑囊虫病患者细胞因子表达特征研究结果,整合中枢和外周细胞因子变化的证据。我们进行了一项meta分析,针对脑囊虫病患者中枢及外周细胞因子浓度与对照组比较的研究。该研究纳入14个研究,共518例脑囊虫病和386个对照包括在内。总体而言,干扰素-γ(IFN-γ)的浓度(P值=0.000 5)和IL-2(P<0.000 01)显著较低,但肿瘤坏死因子-α(TNF-α)(P<0.000 01),IL-4(P=0.000 01),IL-10(P<0.000 01)和sIL-2R(P<0.000 01)在脑囊尾蚴病的患者显著高于对照组。对IL-6和IL-8表达水平在囊虫患者和对照组之间没有显著差异。sIL-2R和IL-6在脑囊虫病患者脑脊液水平显著降低,该结果仅由唯一的一项研究支持。这项分析提示TH1/TH2细胞因子表达失衡可能参与脑囊虫病患者发病机理。Neurocysticercosis is associated with central and peripheral immune system dysfunction;however,the cytokine expressions in individual studies are conflicting.The present paper aims to systematically review evidence of central and peripheral cytokine alterations in neurocysticercosis integrating findings from various affective states.A meta-analysis was conducted in comparison of central and peripheral cytokine concentrations in patients with neurocysticercosis with control subjects.Fourteen articles with a total of 518 neurocysticercosis patients and 386 controls were included.Overall,concentrations of interferon-γ（IFN-γ）（P=0.000 5）and IL-2（P 〈0.000 01）were significantly lower,but tumor necrosis factor-a（TNF-a）（P〈0.000 01）,IL-4（P=0.000 01）,IL-10（P〈0.000 01）and soluble ICAM-1（P〈0.000 01）,sIL-2R（P〈0.000 01）were significantly higher in neurocysticercosis patients compared with controls.There were no significant differences of IL-6and IL-8levels between neurocysticercosis patients and control subjects although sIL-2Rand IL-6were low in CSF of neurocysticercosis patients,which was supported by only one study.These results indicate that a Th1/Th2 imbalance exists in neurocysticercosis,which may be involved in the pathogenesis of the disease.

关 键 词：细胞因子 脑囊虫病 META分析 炎症 生物标志物 

分 类 号：R532.33[医药卫生—内科学]