肾素血管紧张素系统与骨骼肌胰岛素抵抗的关系  

Progress on relationship between renin-angiotensin system and skeletal muscle insulin resistance

作　　者：黄祺[1] 吴文君[1] 卜瑞芳[1] 

机构地区：[1]南京医科大学附属无锡人民医院内分泌科,214000

出　　处：《中华全科医师杂志》2016年第3期228-231,共4页Chinese Journal of General Practitioners

摘　　要：骨骼肌是体内处理葡萄糖的重要组织，也是产生胰岛素抵抗的主要部位之一。经典的肾素血管紧张素系统（RAS）的过度激活会诱导氧化应激，导致骨骼肌胰岛素信号及葡萄糖转运活性受损，从而促进骨骼肌胰岛素抵抗的产生。通过抑制经典的RAS、激活非经典RAS，可以改善骨骼肌胰岛素抵抗。Skeletal muscle is essential for the glucose disposal in organism, which is one of the major sites of insulin resistance. The over-activity of classical renin-angiotensin system （RAS） induces the oxidative stress, leads to the impairment of insulin signaling and glucose transport, resulting in insulin resistance of skeleton muscle. The activation of non-classical RAS by inhibiting classical RAS activity, can ameliorate insulin resistance in skeletal muscle tissue.

关 键 词：肾素-血管紧张素系统 胰岛素抗药性 

分 类 号：R587.1[医药卫生—内分泌]