丹参多酚酸盐联合左卡尼汀治疗稳定型心绞痛的疗效观察  

The clinical effect of levocarnitine combined with salvianolate in the treatment of stable angina

作　　者：楚建杰[1,2] 王艳华[2] 王明明[2] 胡冬梅[2] 郭虎宁[2] 王婧雯[2] 杨志福[2] 文爱东[1,2] 

机构地区：[1]陕西中医药大学药学院,陕西咸阳712046 [2]第四军医大学第一附属医院西京医院药剂科,陕西西安710032

出　　处：《蚌埠医学院学报》2016年第1期57-58,62,共3页Journal of Bengbu Medical College

摘　　要：目的:观察注射用丹参多酚酸盐联合左卡尼汀注射液治疗老年(≥65岁)稳定型心绞痛的疗效。方法:回顾性分析120例老年稳定型心绞痛患者的临床资料。对照组60例给予阿司匹林、硝酸酯类、钙拮抗剂及β-受体阻滞剂等常规治疗;观察组60例在常规治疗基础上应用注射用丹参多酚酸盐联合左卡尼汀注射液,比较2组患者治疗后的临床症状和心电图改善情况。结果:观察组临床症状改善总有效率为90.0%,明显高于对照组的63.3%(P<0.01);观察组心电图改善总有效率为86.7%,显著高于对照组的53.3%(P<0.01)。2组均未发现明显不良反应。结论:注射用丹参多酚酸盐联合左卡尼汀注射液治疗老年稳定型心绞痛能有效缓解患者临床症状,改善缺血心电图,值得临床进一步推广使用。Objective： To observe the clinical efficacy of levocarnitine combined with salvianolate in the treatment of stable angina in elderly patients（ ≥65 years old）. Methods： One hundred and twenty elderly patients with coronary heart disease complicated with stable angina were randomly divided into the observation group and control group（ 60 cases each group）. Both groups were treated with conventional treatment（ including aspirin,nitrates,calcium channel blockers and β-R blockers）. The observation group were additionally treated with levocarnitine combined with salvianolate. The clinical symptoms and electrocardiogram in two groups were observed before and after treatment. Results： The total effective rates of clinical symptoms improvement in the observation group（ 90. 0%） was statistically higher than control group（ 63. 3%）（ P〈0. 01）. The total effective rates of the electrocardiogram improvement in the observation group（ 86. 7%） was statistically higher than control group（ 53. 3%）（ P〈0. 01）. No significant adverse reaction in two groups was found. Conclusions： The treatment of stable angina in elderly patients with coronary heart disease with levocarnitine combined with salvianolate is safe and effective,which can significantly alleviate the clinical symptoms,improve the ischemic electrocardiogram,and is worthy of further promotion in clinic.

关 键 词：心绞痛 稳定型 丹参多酚酸盐 左卡尼汀 

分 类 号：R541.4[医药卫生—心血管疾病]