活体肾移植供者的长期医学风险  

Long-term medical risks to the live kidney donor

作　　者：张喆[1] 陈劲松[2] 

机构地区：[1]第二军医大学金陵医院(南京军区南京总医院)肾脏科,硕士研究生南京210016 [2]第二军医大学金陵医院(南京军区南京总医院)国家肾脏疾病临床医学研究中心全军肾脏病研究所,南京210016

出　　处：《肾脏病与透析肾移植杂志》2016年第1期86-89,共4页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：活体肾脏捐献造福众多终末期肾病(ESRD)患者,但也给供者带来医学风险。尽管15年供者累积ESRD发生率<1%,但其发生ESRD的风险比健康非供者高。然而,供者在捐献后10年内全因死亡率、心血管疾病风险、需要透析治疗的急性肾损伤、需要外科治疗的肾结石的发生率均与健康非供肾者相似。供者痛风的发生率、女性供者发生妊娠期高血压和先兆子痫的风险均比健康非供肾者高。Living kidney donation benefits recipients but carries long-term risks for the donor. Two studies have been reported a higher risk of end-stage renal disease（ ESRD） among donors than among healthy nondonors; however,the absolute 15-year incidence of ESRD was〈 1%. In the first decade after donor nephrectomy,the incidence of all-cause mortality and cardiovascular events among donors seems to be similar to that among healthy matched nondonors,as do the risks of acute kidney injury（ AKI） that requires dialysis,and kidney stones that require surgical intervention. Some evidences suggest that the incidence of gout as well as gestational hypertension or pre-eclampsia in pregnancies is higher among donors than among healthy nondonors.

关 键 词：活体供肾 终末期肾病 急性肾损伤 肾结石 全因死亡率 

分 类 号：R699.2[医药卫生—泌尿科学]