EPO／EPOR对缺血缺氧组织的保护作用  

EPO, EPOR protection Effect for ischemia hypoxia group

作　　者：张召华[1] 崔森[2] 

机构地区：[1]青海大学附属医院,青海西宁810001 [2]青海大学附属医院血液科,青海西宁81000O

出　　处：《医药前沿》2016年第2期12-14,共3页Journal of Frontiers of Medicine

摘　　要：机体或细胞内低氧是许多疾病中常见的一种情况，了解EP0／EPOR在这些疾病中的作用机制，能为缺血缺氧性疾病的防治提供新的方法和思路。持续低氧条件下，机体供氧不足，使组织缺氧，逐渐影响靶器官的功能。缺血再灌注损伤及低氧环境刺激使EPO生成增加，与EPOR结合后共同介导缺血缺氧条件下的一系列生理反应，为组织细胞提供充足的氧和能量，减轻低氧对机体的损伤。本文就EPO／EPOR对缺氧组织的保护作用予以综述。The organism or cell hypoxia is a common situation in many diseases, understanding of EPO/EPOR mechanism in these diseases, to hypoxic ischemia disease prevention provide new method and train of thought. Sustained low oxygen conditions, enough oxygen to the body, make the hypoxia, gradually affect the function of target organs. Ischemia-reperfusion injury and low oxygen environment, increase the EPO generation, combined with EPOR, after a series of physiological reaction mediated ischemia anoxic conditions together, to provide sufficient oxygen and energy for cells, reduce the hypoxic damage in the body. This paper reviews the EPO/EPOR of hypoxia group of protection.

关 键 词：EPO EPOR 缺血缺氧性疾病 缺血再灌注 

分 类 号：R446[医药卫生—诊断学]