社区获得性肺炎患者呼出气冷凝液中降钙素原检测的临床意义  

Clinical significance of procalcitonin detection in exhaled breath condensate of patients with community-acquired pneumonia

作　　者：陈金亮[1] 徐永谦[1] 陶一江[1] 陈建荣[1] 

机构地区：[1]南通市第一人民医院,南通226001

出　　处：《内科急危重症杂志》2016年第1期23-25,共3页Journal of Critical Care In Internal Medicine

基　　金：南通市科技技划项目(No:HS149031)

摘　　要：目的:探讨社区获得性肺炎(CAP)患者呼出气冷凝液(EBC)中降钙素原(PCT)水平在病情评估及疗效评价中的价值。方法:收集72例CAP住院患者第1、3、7天的EBC及血清标本,测定PCT水平。入院时白细胞计数及C反应蛋白(CRP)水平,记录CURB-65评分。另选择同期健康体检者48例作为正常对照组,测定其EBC及血清PCT水平。结果:①CAP组EBC中PCT水平高于正常对照组(P<0.01);②与第1天比较,CAP组第3天和第7天EBC中PCT水平下降(P<0.01);③EBC中PCT水平在高危组、中危组和低危组3组间的差异具有统计学意义(P<0.01);④EBC中PCT水平与血中PCT、CRP、WBC水平和CURB-65评分皆呈正相关。结论:CAP患者EBC中PCT水平与患者病情严重程度具有较好的相关性,是判断CAP严重程度和预后的敏感指标。Objective：To explore the value of procalcitonin（PCT） level in exhaled breath condensate（EBC） in assessment of patients＇ condition and the therapeutic effect of patients with community-acquired pneumonia（CAP）.Methods：EBC and serum samples of 72 inpatients with CAP were collected on 1^（st）,3^（rd）,7^（th） day of admission,and levels of PCT,leukocyte count and C-reactive protein（CRP） were detected,CURB-65 score were recorded at admission.Another 48 healthy screening people as the normal control group.Results：①Compared with that of normal control group,the PCT levels in EBC were higher（P 0.01）.②The PCT levels in EBC decreased on 3^（rd） day and 7^（th） day compared with those of on 1^（st） day（P 0.01）.③There was significant difference in level of PCT in EBC among high,median and low risk score groups（P 0.01）.④The level of PCT in EBC was positively related with serum PCT,CRP,WBC and CURB-65 score（P 0.01）.Conclusions：There is a good correlation between the level of PCT in EBC and the severity of the disease,suggesting that PCT is a sensitive predictor for the severity and prognosis of CAP.

关 键 词：社区获得性肺炎 呼出气冷凝液 降钙素原 CURB-65评分 临床意义 

分 类 号：R563.1[医药卫生—呼吸系统]