一种合成多氟联苯类化合物的新方法  

A New Method for Synthesis of Multiple Fluorine Substituted Biaryl Compounds

作　　者：计燕萍[1] 杨芸[1] 高广春[1] 

机构地区：[1]嘉兴学院医学院药学系,浙江嘉兴314001

出　　处：《合成化学》2016年第3期259-262,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以Cu I为催化剂,芳胺与多氟苯经重氮化/偶联一锅反应合成了6个多氟取代的联苯类化合物(3a^3f),收率56%~82%,其结构经1H NMR,19F NMR和EI-MS确证。在最佳反应条件[1a 2 mmol,20%Cu I为催化剂,150%四丁基碘化铵为碘化试剂,V(DMSO)∶V(Me CN)=1∶1为溶剂,于130℃反应4 h]下,3a收率75%。A new one-pot synthetic method to prepare multiple fluorine substituted biaryl compounds（ 3a ~ 3f） by diazotization /cross-coupling of aromatic anilines with polyuoroarenes had been developed. The yields were 56% ~ 82%. The structures were confirmed by1 H NMR,19 F NMR and EIMS. Under the optimized conditions[1a 2 mmol,20% Cu I as the catalyst,150% Bu4 NI as the iodide reagent,V（ DMSO） ∶ V（ Me CN） = 1 ∶ 1 as the solvent,at 130 ℃ for 4 h],the yield of 3a was 75%.

关 键 词：偶联反应 重氮化反应 多氟联苯 合成 

分 类 号：TQ241.3[化学工程—有机化工] O621.3[理学—有机化学]