痰瘀互结型围绝经期冠心病患者的临床特点研究  

Clinical Features of Perimenopausal Patients With Coronary Heart Disease of Phlegm-blood Stasis Syndrome Type

作　　者：余英[1] 冯妍[1] 王以新[1] 马立萍[1] 杨敏京[1] 郭芳[1] 乔曼丽[1] 

机构地区：[1]首都医科大学附属北京安贞医院全科医疗科,北京市100029

出　　处：《中国全科医学》2016年第7期857-861,共5页Chinese General Practice

基　　金：北京市自然科学基金资助项目(7144205);首都医科大学附属北京安贞医院院长科技发展基金项目(2013Z05);首都卫生发展科研专项批准项目(2014-3-2063;2014-2-1053)

摘　　要：目的分析痰瘀互结型围绝经期冠心病患者的临床特点。方法选取2012年12月—2014年6月首都医科大学附属北京安贞医院收治的痰瘀互结型围绝经期冠心病患者143例为观察组;根据年龄和合并症情况,配对选择非痰瘀互结型围绝经期冠心病患者143例为对照组。比较并分析两组的基本情况、实验室检测指标及超声心动图检查结果。结果两组平均年龄和合并高血压、糖尿病、高脂血症情况比较,差异无统计学意义(P>0.05);两组合并心肌梗死情况和冠状动脉病变情况比较,差异有统计学意义(P<0.05)。两组总胆固醇(TC)、低密度脂蛋白(LDL)、载脂蛋白A1(Apo A1)、载脂蛋白B(Apo B)及脂蛋白(a)〔Lp(a)〕比较,差异无统计学意义(P>0.05);两组空腹血糖(FPG)、三酰甘油(TG)、高密度脂蛋白(HDL)及极低密度脂蛋白(VLDL)比较,差异有统计学意义(P<0.05)。两组丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血清总蛋白(TP)、清蛋白(ALB)、尿素氮(BUN)、肌酐(Cr)及尿酸(UA)比较,差异无统计学意义(P>0.05)。两组γ-谷氨酰转移酶(γ-GT)、α-淀粉酶(α-AMY)、C反应蛋白(CRP)、红细胞比容(HCT)及平均红细胞血红蛋白量(MCH)比较,差异无统计学意义(P>0.05);两组纤维蛋白原(FIB)比较,差异有统计学意义(P<0.05)。两组左心房内径、左心室舒张末期内径、室间隔厚度、左心室后壁厚度及左心室射血分数比较,差异无统计学意义(P>0.05)。结论痰瘀互结型围绝经期冠心病患者较非痰瘀互结型患者更容易出现糖脂代谢紊乱,冠状动脉病变程度更严重,心肌梗死发生风险更高。Objective To analyze the clinical features of perimenopausal patients with coronary heart disease of phlegm- blood stasis syndrome type. Methods We enrolled 143 perimenopausal patients with coronary heart disease of phlegm-blood stasis syndrome type who were admitted into Beijing Anzhen Hospital Affiliated to Capital Medical University from December2012 to June 2014 as observation group; 143 perimenopausal patients with coronary heart disease of non phlegm- blood stasis syndrome type were also enrolled based on the match- up of age and complication. Comparison was made between the two groups in basic information,laboratory results and ultrasonic cardiogram results. Results The two groups were not significantly different in average age,complication with hypertension,diabetes and hyperlipidaemia（ P〉0. 05）; the two groups were significantly different in myocardial infarction and coronary artery disease（ P〈0. 05）. The two groups were not significantly different in TC,LDL,Apo A1,Apo B and Lp（a）（P〉0. 05）; the two groups were significantly different in FPG,TG,HDL and VLDL（P〈0. 05）. The two groups were not significantly different in ALT,AST,TP,ALB,BUN,Cr and UA（ P〉0. 05）. The two groups were not significantly different in γ-GT,α-AMY,CRP,HCT and MCH（ P〈0. 05）; the two groups were significantly different in FIB（ P〈0. 05）. The two groups were not significantly different in left atrial diameter,left ventricular end diastolic diameter,interventricular septal thickness,left ventricular posterior wall thickness and left ventricular ejection fraction（ P〉0. 05）. Conclusion Perimenopausal patients with coronary heart disease of phlegm- blood stasis syndrome type are more likely to have glucose and lipid metabolism disorder and have severer coronary artery disease and higher risk for myocardial infarction.

关 键 词：冠心病 围绝经期 痰瘀互结证 临床特点 

分 类 号：R541.4[医药卫生—心血管疾病]