冷水七的化学成分研究  

Chemical constituents from Impatiens pritzllii var. hupehensis

作　　者：张建超[1] 贺文军[2] 刘焱文 谭宁华[2] 

机构地区：[1]湖北中医药大学药学院,湖北武汉430065 [2]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650201 [3]湖北省中药资源与中药化学重点实验室,湖北武汉430061

出　　处：《中国中药杂志》2016年第1期83-86,共4页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2011ZX09307-002-02);云南省自然科学基金项目(2012GA003)

摘　　要：通过正丁醇萃取、硅胶柱色谱、Sephadex LH-20以及HPLC等色谱手段对凤仙花科凤仙花属植物冷水七的50%乙醇提取物进行分离纯化,并结合1D-NMR,2D-NMR,HRESI-MS等数据进行结构鉴定。共分离鉴定8个化合物,1为新化合物,命名为2,6-dimethyl-2-vinyl-2,3,4,7-tetrahydrooxepine(1),其余7个为已知化合物,分别是1,3,6-trihydroxy-7-methyl-anthraquinone(2),4-hydroxybenzaldehyde(3),4-(3-methoxy-4-hydroxyphenyl)-2-butanone(4),podophyllotoxin(5),scopoletin(6),α-spinasterol(7)和3-O-β-D-glucopyranosyl-α-spinasterol(8)。以上已知化合物均为首次从该植物中分离得到。Eight compounds were isolated from the 50% ethanol extract of Impatiens pritzllii var. hupehensis through various column chromatography methods including silica gel,Sephadex LH-20,and preparative HPLC. Their structures were elucidated as 2,6-dimethyl-2-vinyl-2,3,4,7-tetrahydrooxepine（ 1）,1,3,6-trihydroxy-7-methyl-anthraquinone（ 2）,4-hydroxybenzaldehyde（ 3）,4-（ 3-methoxy-4-hydroxyphenyl）-2-butanone（ 4）,podophyllotoxin（ 5）,scopoletin（ 6）,α-spinasterol（ 7） and 3-O-β-D-glucopyranosyl-α-spinasterol（ 8） based on the NMR and MS spectral data. Compound 1 is new compound and compounds 2-8 are isolated from this plant for the first time.

关 键 词：冷水七 化学成分 2 6-dimethyl-2-vinyl-2 3 4 7-tetrahydrooxepine 

分 类 号：R284.1[医药卫生—中药学]