围孕期服用叶酸营养素软胶囊预防神经管畸形的疗效观察  

Wai Folic Acid During Pregnancy Nutrients Curative Effect Observation of Soft Capsule to Prevent Neural Tube Defects

作　　者：王民 

机构地区：[1]河北省青龙满族自治县生殖保健医院,河北青龙066599

出　　处：《河北医学》2016年第3期450-453,共4页Hebei Medicine

基　　金：河北省秦皇岛市2015年科技计划(第二批)科技支撑项目;(编号:201502A150)

摘　　要：目的：探讨育龄妇女围孕期服用叶酸营养素软胶囊（小剂量叶酸增补剂＋B族维生素＋微量元素）预防神经管畸形（NTDS）的临床疗效。方法：对1600名自愿参加实验的计划怀孕的育龄妇女,随机抽取并分为两组：实验组（A组）800例,从计划怀孕开始,服用叶酸营养素软胶囊3-6个月;对照组（B组）800例,除进行必要的优生优育知识教育外,不服用任何叶酸类药物,从孕16周至结束分娩,对出现的神经管畸形（NTDS）率进行统计分析,对比观察服用叶酸营养素软胶囊后预防神经管畸形的临床疗效。结果：A组800名妇女出现神经管畸形2例;而B组800名妇女出现神经管畸形10例,A组发生率为2.50‰（2/800）,B组发生率为12.5‰（10/800）,两组神经管畸形发生率有显著性差异（P〈0.05）;同时也发现孕前3个月开始服用叶酸营养素软胶囊者占70%（560/800）,孕前2个月开始服用者占26.75%（214/800）,孕前1个月开始服用者占3.33%（26/800）。连续服用3个月者占20.75%（166/800）,连续服用4-6个月者占79.25%（634/800）,无论是在服药时长,还是孕前服药开始时间上,生育一胎的妇女人数都明显高于生育第二胎的育龄妇女人数。结论：叶酸营养素软胶囊既是小剂量叶酸增补剂,又含有孕期妇女所需要的水溶性维生素、铁、锌、硒等多种微量元素,围孕期服用可以更好地预防和减少NTDS的发生,能有效降低神经管畸形的发生率,因此推广育龄妇女围孕期服用叶酸营养素软胶囊很有必要,值得大力提倡。Objective： To invastigate women of childbearing age taking folic acid during pregnancy nutrients around soft capsule（ small dose of folic acid supplements ＋ B vitamins,trace elements） to prevent neural tube defects（ NTDS） clinical curative effect. Method： 1600 pregnant women of childbearing age,volunteered for the experiment plan and randomly divided into two groups with 800 cases in each groups. Experimental group（ group A）,from planning pregnancy,were given folic acid nutrients soft capsule for three to six months. Control group（ group B） were not given any folic acid,in addition to the necessary knowledge education of eugenic and superior nurture. From 16-week pregnancy till birth,the rate of neural tube defects（ NTDS） was statistically analyzed,comparative observation taking folic acid nutrients soft capsule after the clinical curative effect of the prevention of neural tube defects. Result： 2 cases with neural tube defect in group A emerged; 10 cases in group B emerged. The incidence of group A was 2. 50%（ 2 /800）,group B rate was 12. 5%（ 10 /800）. The difference were statistically significant（ P〈0. 05）; Taking folic acid nutrients soft capsule during the first three months was 70%（ 560 /800）,2 months before pregnancy accounted for26. 75%（ 214 /800）,1 month before childbirth users accounted for 3. 33%（ 26 /800）. The users taking it continuously for 3 months was 20. 75%（ 166 /800）,for 4-6 months was 79. 25%（ 643 /800） whether in the medication time or medicated before the start time,the number in first birth was significantly higher than the second birth in the number of women of childbearing age. Conclusion： Women of childbearing age taking folic acil can prevent and reduce the occurrence of NTDS,can effectively reduce the incidence of neural tube defects. thus is necessary during pregnancy nutrients,which is worth promoting.

关 键 词：围孕期 叶酸营养素软胶囊 神经管畸形 

分 类 号：R715.3[医药卫生—妇产科学]