硅掺杂纳米羟基磷灰石:溶解度、抗折和抗压强度解析  

Silicon-doped nano-hydroxyapatite: solubility, anti-fracture and compressive strengths

作　　者：程瑶[1] 王星星[1] 汪大林[1] 

机构地区：[1]解放军第二军医大学第一附属医院长海医院,上海市200433

出　　处：《中国组织工程研究》2016年第3期435-440,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(51232007)~~

摘　　要：背景:硅掺杂纳米羟基磷灰石具有良好的生物相容性和生物学活性,作为一种新兴生物学材料具有广泛应用前景。目的:概述硅掺杂纳米羟基磷灰石的制备过程、原理、方法,以及不同掺杂方法对羟基磷灰石溶解度、表面形态及体内体外生物学效应的影响。方法:由第一作者用计算机检索中国期刊全文数据库(1990至2015年)、Medline(1990至2015年)数据库,检索词分别为"硅、纳米羟基磷灰石、生物材料、生物学、组织工程、骨修复;silicon,nano-hydroxyapatite,biological material,tissue engineering,bone repair"。结果与结论:硅掺杂纳米羟基磷灰石的制备方法可以分为液相法和固相法两大类。硅掺杂可增加纳米羟基磷灰石的溶解度、抗折和抗压强度,促进纳米羟基磷灰石的成骨作用,但不同掺杂方法和掺杂比重对羟基磷灰石的影响不同,还需要进一步的研究筛选与优化。BACKGROUND： Silicon-doped nano-hydroxyapatite has good biocompatibility and bioactivity, and has broad application prospect as a new biological material. OBJECTIVE： To summarize the preparation process, principle, method of silicon-doped nano-hydroxyapatite and the effect of different doping methods on the solubility, surface morphology and the in vitro and in vivo biological effects of hydroxyapatite.METHODS： The first author searched China National Knowledge Infrastructure（1990-2015）, and Medline database（1990-2015） for related articles using the key words of ＂silicon, nano-hydroxyapatite, biological material,biology, tissue engineering, bone repair＂ in Chinese and English, respectively. RESULTS AND CONCLUSION： The preparation methods of silicon-doped nano-hydroxyapatite can be divided into two kinds： liquid phase method and solid phase method. Silicon doping can increase the solubility, anti-fracture and compressive strengths of nano-hydroxyapatite, and promote the osteogenesis of nano-hydroxyapatite, but the effects of different doping methods and specific gravity on the hydroxyapatite are different. Further research screening and optimization are still needed.

关 键 词：硬羟基磷灰石 硅 组织工程 生物材料 材料相容性 硅元素 羟基磷灰石 生物学效应 综述 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]