单唾液酸四己糖神经节苷脂钠穴位注射联合针刺对新生儿缺血缺氧性脑病RCBF及CK-BB的影响  

The Effect of Acupuncture Combined with Acupoint Injection of Monosialotetrahexosylganglioside Sodium on RCBF and CK-BB of Neonatal Hypoxic Ischemic Encephalopathy

作　　者：罗秀玲[1] 戴欣钰[1] 冯艳琴[1] 赵凌艳[1] 穆敬平[1] 

机构地区：[1]湖北省十堰市太和医院(附属湖北医药学院),湖北十堰442000

出　　处：《中国中医急症》2016年第3期400-402,407,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：湖北省科技厅资助项目(2013cfc037)

摘　　要：目的观察单唾液酸四己糖神经节苷脂钠穴位注射联合针刺对新生儿缺血缺氧性脑病的临床疗效,探索中西医结合的综合治疗方案。方法 170例患儿随机分常规治疗组、联合治疗组各85例。常规治疗组每日静滴胞二磷胆碱、吸氧等对症支持治疗,联合治疗组在此基础上施平补平手法,取体针、头针针刺20 min,并用单唾液酸四己糖神经节苷脂钠穴位注射。采用新生儿20项神经行为评分办法(NBNA)评分,统计总有效率,动态观察治疗前、治疗后7、14、28 d局部脑血流量(RCBF)、脑电图(EEG)病理性棘波振幅;测定血浆肌酸激酶同工酶BB(CK-BB)。结果联合治疗组总有效率97.65%,优于常规治疗组的90.59%(P<0.05)。两组在治疗14、28 d后与治疗前比较,均明显改善(均P<0.05),且联合治疗组NBNA明显高于常规治疗组,CKBB低于常规治疗组(均P<0.05)。两组在治疗14、28 d时RCBF均有升高,EEG棘波则均下降(均P<0.05),且联合治疗组明显优于常规治疗组(均P<0.05)。结论头针、体针针刺可疏通缺血缺氧性脑病新生儿经络、激发经气,松弛脑缺血新生儿血管平滑肌、改善微循环而增加局部脑血流量,单唾液酸四己糖神经节苷脂钠穴位注射吸收后营养修复受损神经,促进脑能量代谢而起到治疗作用。Objective： To observe the therapeutic effect of acupuncture combined with acupoint injection of monosialotetrahexosylganglioside sodium on RCBF and CK-BB of neonatal hypoxic ischemic encephalopathy,and to explore the comprehensive treatment plan of Chinese medicine and Western medicine. Methods： 170 cases were randomly divided into the conventional group and the combined group,with 85 cases in each. The conventional group received symptomatic supportive treatment,such as intravenous drip of citicoline,oxygen inhalation,and so on. On the basis of the conventional group,the combined group was given a flat and complementary technique,with 20minutes′ body acupuncture and scalp acupuncture and acupoint injection of monosialotetrahexosylganglioside sodium. NBNA was adopted to evaluate the scores. Total effective rate is statistical. Dynamic observa-tion was detected to get the RCBF,EEG and CK-BB before treatment and on 7th,14 th and 28 th day after treatment. Results： The total effective rate of the combined group was 97.65%,which was better than that of the conventional group 90.59%（P〈 0.05）. The two groups on 14 th and 28 th day after treatment were improved more before treatment（all P〈 0.05）. NBNA of the combined group was obviously higher than that of the conventional group,and CK-BB of the combined group was lower than that of the conventional group（all P〈 0.05）. On 14 th and 28 th day,BCBF of both groups rose,and spike wave of EEG dropped（all P〈 0.05）,and the combined group was superior to the conventional group（all P〈 0.05）. Conclusion： Body acupuncture and scalp acupuncture can dredge the channel,stimulate Qi,relax vascular smooth muscle,and improve microcirculation to increase local cerebral blood flow of the neonate with neonatal hypoxic ischemic encephalopathy. Acupuncture combined with acupoint injection of monosialotetrahexosylganglioside sodium can promote the absorption of nutrition and repair damaged nerve,so as to promote the brain energy metabolism and play a th

关 键 词：新生儿缺血缺氧性脑病 针刺联合穴位注射 单唾液酸四己糖神经节苷脂钠 局部脑血流 脑电图 

分 类 号：R245[医药卫生—针灸推拿学]