山桔叶水提物镇痛抗炎作用  

Analgesic and Anti-inflammatory Effects of the Water Extract of Glycosmis citrifolia(Willd.) Lindl.

作　　者：黄丽贞[1] 侯宁宁[1] 马雯芳[1] 吴海静[1] 邓秀珍[1] 唐标[1] 

机构地区：[1]广西中医药大学药学院,南宁530001

出　　处：《医药导报》2016年第3期233-236,共4页Herald of Medicine

基　　金：广西自然科学基金资助项目(2013GXNSFBA019137);广西高校科学技术研究项目开发计划资助项目(2013YB128);广西卫生厅资助项目(Z2012191)

摘　　要：目的研究山桔叶水提物对小鼠的镇痛抗炎作用,并探讨其作用机制。方法采用0.7%醋酸致小鼠扭体反应、热板仪致小鼠疼痛、二甲苯致小鼠耳廓肿胀、1%角叉菜胶致小鼠足肿胀及测定炎足中前列腺素E2(PGE2)含量、0.6%醋酸致小鼠腹腔毛细血管通透性增加、小鼠棉球肉芽肿方法,观察山桔叶水提物镇痛抗炎作用。结果山桔叶水提物大、中、小剂量组醋酸致小鼠扭体反应次数减少(P<0.01或P<0.05),提高热板致小鼠疼痛的痛阈值(P<0.01或P<0.05);抑制二甲苯致小鼠耳廓肿胀度(P<0.01或P<0.05)、1%角叉菜胶致小鼠炎足肿胀(P<0.01或P<0.05)、1%角叉菜胶致小鼠炎足PGE2产生(P<0.01)、0.6%醋酸致小鼠腹腔通透性增加(P<0.05)及小鼠棉球肉芽肿产生(P<0.01或P<0.05)。结论山桔叶水提物对小鼠有镇痛抗炎作用。Objective To observe the analgesic and anti-inflammatory effects of the water extract of Glycosmis citrifolia （Willd.） Lindl.on mice and explore the mechanism. Methods The analgesic and anti-inflammatory effects were evaluated by 0.7% acetic acid-induced writhing test,the hot plate test,tests of dimethylbenzene-induced ear swelling,1% carrageenan-induced paw edema,determination of PGE2 in inflammatory feet,0.6% acetic acid-induced increase in peritoneal capillary permeability and cotton ball granuloma. Results The water extract of Glycosmis citrifolia （Willd.） Lindl.at low,medium and high doses can reduce the acetic acid-induced writhing times （P〈0.01 or P〈0.05）,increase the pain threshold of mice （P〈0.01 or P〈0.05）, inhibit dimethylbenzene-induced ear swelling （P〈0.01 or P〈0.05）,1% carrageenan-induced paw edema （P〈0.01 or P〈0.05） and PGE2 production （P〈0.01）,0.6% acetic acid-induced increase of peritoneal capillary permeability （P〈0.05）,and the de-velopment of cotton ball granuloma （P〈0.01 or P〈0.05）. Conclusion The water extract of Glycosmis citrifolia （Willd.） Lindl.shows analgesic and anti-inflammatory effects on mice.

关 键 词：山桔叶水提物 镇痛作用 抗炎作用 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]