右美托咪定和咪达唑仑对COPD急性加重期机械通气患者镇静效果的比较  

Sedative Effect between Dexmedetomidine and Midazolam on COPD Patients with Acute Aggravating Period of Mechanical Ventilation

作　　者：王正卫 叶培军 吴贺文 

机构地区：[1]郑州大学附属肿瘤医院重症医学科,河南郑州450008

出　　处：《中国医药指南》2016年第7期29-30,共2页Guide of China Medicine

摘　　要：目的比较右美托咪定和咪达唑仑对COPD急性加重期机械通气患者的镇静效果差异。方法选择在本院接受治疗的COPD急性加重期患者作为研究对象,随机分为接受右美托咪定治疗的观察组及接受咪达唑仑治疗的对照组,比较两组患者的治疗后呼吸及血压、停药后清醒、机械通气及ICU治疗时间等差异。结果观察组患者接受镇静治疗后的RR、HR、MAP值低于对照组,Sp O_2值高于对照组患者(P<0.05);观察组患者接受右美托咪定镇静治疗后的停药后清醒时间、机械通气持续时间及ICU总治疗时间均显著短于对照组患者(P<0.05)。结论右美托咪定镇静治疗有助于优化COPD急性加重期机械通气患者的呼吸机血压指标、缩短机械通气治疗时间。Objective To analysis Sedative effect between dexmedetomidine and midazolam on COPD patients with acute aggravating period of mechanical ventilation. Methods Choosed COPD patients with acute aggravating period and mechanical ventilation in our hospital as research object, randomly divided into observation group received dexmedetomidine treatment and control group received midazolam, compared two group patients＇ respiratory and blood pressure, sober, mechanical ventilation and ICU treatment time. Results observation group patients＇ RR, HR, MAP values after treatment were lower than control group, Sp O_2 value was higher than control group patients（P〈0.05）; observation group patients＇ waking time, duration of mechanical ventilation and total ICU treatment time were significantly shorter than control group（P〈0.05）. Conclusion Dexmedetomidine calm treatment for COPD patients with acute aggravating period and mechanical ventilation could improve blood pressure index, shorten time of mechanical ventilation treatment.

关 键 词：COPD 机械通气 右美托咪定 咪达唑仑 

分 类 号：R614[医药卫生—麻醉学]