降钙素原与C反应蛋白联合检测在儿童支气管肺炎及细菌性肺炎中的应用评价  

Application of combined determination of serum procalcitonin and CRP in children with bronchial pneumonia and bacterial pneumonia

作　　者：张珍[1] 白威峰[2] 

机构地区：[1]安徽省蚌埠市第一人民医院检验科,233000 [2]安徽省蚌埠市第一人民医院核医学科,233000

出　　处：《淮海医药》2016年第2期155-156,共2页Journal of Huaihai Medicine

摘　　要：目的:评价联合检测降钙素原(PCT)和C反应蛋白(CRP)水平变化在儿童支气管肺炎及细菌性肺炎患者疗效及预后判断中的临床意义。方法:2014年2月-2015年2月儿科综合病区102例支气管肺炎及细菌性肺炎儿童血清标本,其中支气管肺炎55例,细菌性肺炎47例,另将35名健康的儿童作为对照组。用化学发光法和乳胶凝集法分别检测其血清PCT及CRP水平。结果:以PCT>0.5 ng/ml及CRP>10 mg/L作为阳性判断标准,支气管肺炎及细菌性肺炎组血清PCT和CRP的阳性率明显高于对照组(P<0.01);同时,支气管肺炎及细菌性肺炎组血清中的PCT和CRP的水平也明显高于对照组(P<0.01);再经过有效抗菌药物治疗后,支气管肺炎及细菌性肺炎组血清中的PCT和CRP的水平明显降低(P<0.01)。结论:血清PCT及CRP联合测定能够对儿童支气管肺炎和细菌性肺炎的鉴别诊断具有重要的参考价值,而动态监测PCT、CRP的变化更有助于评估疾病的进展和预后。Objective： To evaluate the clinical significance of combined determination of serum procalcitonin（ PCT） and C reactive protein（ CRP） in the curative effect and prognosis in children with bronchial pneumonia and bacterial pneumonia. Methods： From February 2014 to February 2015,a total of 102 blood samples were collected from children who had been diagnosed with bronchial pneumonia and bacterial pneumonia in pediatric department of our hospital. Among them,55 were diagnosed with bronchial pneumonia,47 with bacterial pneumonia. At the same time 35 healthy children were chosen as a control group. Serum PCT and CRP levels were analyzed by using chemiluminescence method and latex agglutination. Results： PCT level exceeding 0. 5 ng / ml and CRP level exceeding 10 mg / L in serum was judged as positive. The positive rates of PCT and CRP in the bronchial pneumonia and bacterial pneumonia group were significantly higher than those in the control group（ P〈0. 01）. Meanwhile,serum PCT and CRP levels for the bronchial pneumonia and bacterial pneumonia group were significantly higher than those of the control group（ P〈0. 01）. The changed levels of PCT and CRP in the bronchial pneumonia and bacterial pneumonia group after the effective antibiotic treatment were statistically significant（ P〈0. 01）.Conclusion： The combined determination of serum PCT and CRP levels are of important value for differential diagnosis of childhood with bronchial pneumonia and bacterial pneumonia. Dynamically monitoring serum PCT and CRP level will contribute to evaluating progress and prognosis of the disease.

关 键 词：支气管肺炎 肺炎 细菌性 降钙素原 C反应蛋白 儿童 

分 类 号：R563.12[医药卫生—呼吸系统] R563.19[医药卫生—内科学]