纳米药物输送系统提高肿瘤多肽疫苗效应的研究进展  

Research Progress of Nanoparticle Drug Delivery Systems Designed to Improve Cancer Peptide Vaccines

作　　者：赵妍[1] 孟胜男[1] 

机构地区：[1]中国医科大学药学院药剂学教研室,沈阳110122

出　　处：《中国药学杂志》2016年第6期437-441,共5页Chinese Pharmaceutical Journal

摘　　要：作为一种新的治疗策略,免疫疗法正让抗肿瘤治疗步入"新时代",肿瘤多肽疫苗也随之展现出良好的应用前景。将纳米药物输送系统应用于肿瘤多肽疫苗,成为近年来的研究热点。纳米药物输送系统作为纳米佐剂,具有提高多肽稳定性、靶向传递抗原、促进抗原的摄取和递呈、激活抗原特异性免疫应答等作用;可通过多种途径提高肿瘤多肽疫苗的免疫效应和治疗效果。笔者结合国内外研究前沿,对纳米药物输送系统提高肿瘤多肽疫苗免疫应答的作用机制、递药模式、药效学等内容进行归纳和总结。同时,对纳米药物输送系统递送肿瘤多肽疫苗所面临的困境进行了初步分析和展望。As a new treatment strategy, immunotherapy has been leading oncotherapy into a new era, and cancer peptide vaccine has been developed as a promising prospect. In recent years applying nanoparticle drug delivery systems to the development of cancer peptide vaccines has became the research hotspot. As nanoparticle-based adjuvants, nanoparticle drug delivery systems can enhance immune response and therapeutic effect through various ways. In this review, we introduce the role of nanoparticle drug delivery systems in cancer peptide vaccines, particularly focusing on several kinds of nanoparticle drug delivery systems for improving immune response of cancer peptide vaccines. Finally, the challenges of applying nanoparticle drug delivery systems to deliver cancer peptide vac- cines are nreliminarv analyzed, and the nrosnect is looked into.

关 键 词：肿瘤免疫治疗 纳米药物输送系统 肿瘤多肽疫苗 纳米佐剂 

分 类 号：R944[医药卫生—药剂学]