血管内皮细胞衰老与血管疾病  

Vascular Endothelial Cell Senescence and Vascular Diseases

作　　者：孟梅[1,2,3] 熊兴东[1,2,3] 

机构地区：[1]广东医学院衰老研究所,广东东莞523808 [2]广东医学院生物化学与分子生物学研究所,广东湛江524023 [3]广东省医学分子诊断重点实验室,广东东莞523808

出　　处：《中国生物化学与分子生物学报》2016年第3期253-259,共7页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.81370456;No.81000143);广东省自然科学基金重点项目(No.2014A030311015);广东省高等学校高层次人才项目(No.GK1318);东莞市社会科技发展项目(No.2013108101057)资助~~

摘　　要：细胞衰老是指细胞在各种应激条件下出现周期阻滞,不可逆地丧失增殖能力,其形态、基因表达和功能都发生特定变化的过程。研究表明,血管内皮细胞衰老可以通过削弱血管功能,促进衰老相关血管疾病的发生发展。然而,有关内皮细胞衰老的发生机制以及内皮细胞衰老影响血管功能及衰老相关血管疾病的潜在机制尚待挖掘。本文从血管内皮细胞衰老相关的信号通路,以及血管内皮细胞衰老与血管功能和血管相关疾病(动脉粥样硬化、高血压和糖尿病血管并发症)的最新研究进展进行综述,为进一步认识血管疾病的发病机制,延缓血管衰老提供新的思路。Cell senescence is manifested as irreversible proliferation arrest in response to various types of stress,which is accompanied by specific changes in cell function,morphology and gene expression.Growing evidence demonstrated that most molecules involved in cellular senescence of endothelial cells were able to influence vascular physiological functions and contributed age-related vascular diseases. In this review,we summarized the recent progress on the endothelial senescence-related signaling pathways,and the effects of endothelial senescence on the vascular functions and diseases of atherosclerosis,hypertension and the vascular complications in diabetes mellitus. It may help to understand the molecular mechanisms of endothelial cell senescence, particularly on how vascular endothelial cells become senescent and how the senescence causes vascular dysfunction and contributes to vascular diseases.

关 键 词：血管内皮细胞 细胞衰老 信号通路 血管功能 血管疾病 

分 类 号：Q74[生物学—分子生物学] R34[医药卫生—基础医学]