赠卵试管婴儿临床结局及其影响因素的研究  

Analysis of outcomes of IVF/ICSI with donor oocytes and relevant impact factors

作　　者：杨纯[1] 耿育红[1] 高颖[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科,武汉430022

出　　处：《生殖医学杂志》2016年第3期209-213,共5页Journal of Reproductive Medicine

摘　　要：目的探讨赠卵试管婴儿供/受卵双方临床结局及相关影响因素。方法回顾性分析2010年1月至2014年5月在我院行体外受精-胚胎移植(IVF-ET)并自愿捐卵的34例患者及同期接受赠卵并完成IVF-ET周期的34例患者的受精率、胚胎着床率、妊娠率的差异。结果受卵组采用卵胞浆内单精子注射(ICSI)授精的比例显著高于供卵组(58.85%vs.23.53%,P<0.01),且受精率(73.87%vs.53.48%)及优质胚胎率(93.87%vs.81.16%)均显著高于供卵组(P<0.001);供卵组和受卵组冻融胚胎移植(FET)周期临床妊娠率分别为60.0%(24/40)和45.45%(20/44),无统计学差异(P>0.05),但供卵组FET周期种植率显著高于受卵组(41.18%vs.26.37%,P<0.05);两组间冻融囊胚移植周期临床妊娠率、囊胚种植率、流产率均无统计学差异(P>0.05)。结论赠卵试管婴儿是治疗卵巢功能低下患者的有效方法,赠卵8枚左右不影响供者妊娠结局;受卵者采用ICSI授精并囊胚移植,或可改善临床妊娠率。Objective： To investigate the outcomes of IVF/ICSI with donor oocytes and relevant impact factors. Methods： The data of IVF/ICSI outcomes of 34 oocyte recipients and 34 oocyte recipients in our hospital from Jan. 2010 to May 2012 were retrospectively analyzed. Results： The proportion of using ICSI technique（58.85% vs. 23.53%, P〈0.01）, fertilization rate （73.87% vs. 53. 48% , P 〈 0. 001） and high quality embryo rate （93.87% vs. 81.16%,P〈0.001） in recipient group were significantly higher than those in donor group. Implantation rate in freeze embryo transfer （FET） cycles in donor group was significantly higher than that in recipient group （41.18% vs. 26.37% ,P〈0. 05）,while there was no significant difference in clinical pregnancy rate [60. 0% （24/40） vs. 45.45% （20/44）] between the two groups （P〉0.05）. There were also no significant differences in clinical pregnancy rate, implantation rate or miscarriage rate of blastocyst FET cycles between the two groups （P〉0.05）. Conclusions： Oocyte donation IVF treatment is effective for the patients with poor ovarian response. Donating eight oocytes does not affect the clinical outcomes of donors. Adopting ICSI technology and blastocyst implantation could improve the implantation and clinical pregnancy rates in oocyte recipients.

关 键 词：卵巢早衰 赠卵 体外受精一胚胎移植 妊娠结局 囊胚培养 

分 类 号：R713.9[医药卫生—妇产科学]