中药柚皮苷诱导成骨作用的研究进展  

Research progress of effects of Naringin on osteogenic induction

作　　者：张乐其[1] 柳毅 徐高丽 徐涛涛[3] 郭婧[1] 霍光[1] 

机构地区：[1]浙江中医药大学口腔医学院牙周科,浙江杭州310053 [2]荷兰阿姆斯特丹牙科学术中心种植与修复科 [3]浙江中医药大学第一临床医学院骨科,浙江杭州310053

出　　处：《口腔医学》2016年第3期277-280,共4页Stomatology

基　　金：国家自然科学基金(81400475);浙江省中医药科技计划项目(2014ZB028)

摘　　要：柚皮苷(NG)作为中药骨碎补有效成分被广泛用于临床上治疗大面积骨缺损及骨质疏松。借助微波、超声等先进技术使柚皮苷有效成分的提取高效简便易行。研究者对柚皮苷的成骨机制进行了大量的体内体外试验研究,体外实验中发现NG可促进骨髓间充质干细胞多种细胞因子及蛋白的表达,如碱性磷酸酶、骨保护素和骨桥蛋白等。在体内实验中NG可使造模动物的骨密度增高,促进肢体活血化瘀进一步促进骨折愈合,且其效果呈剂量相关性。并可协同其他因子通过MAPK通路、骨形态发生蛋白-2等通路促进成骨细胞分化增殖。此外,NG可与一些具有生物相容性的无机支架材料结合,形成复合材料或生物膜,其作为新型骨修复材料具有一定的临床应用前景。As an effective component of rhizoma drynariae,Naringin（ NG） has been widely used in curing severe bone defect and osteoporosis in clinic. Advanced techniques such as microwave and ultrasound have made it efficient and convenient to extract the effective component of Naringin. Researchers have done a lot of experiments in vitro and in vivo to research the mechanism of Naringin. In vitro experiments have revealed that NG can promote the expression of various cytokines and proteins in bone marrow stromal stem cells,such as alkaline phosphatase,osteoprotegerin,and osteopontin. Furthermore,it has been found that NG can increase the bone density of model animals and promote the circulation of blood so as to accelerate fracture healing,which is dose dependent. Moreover,NG can promote osteogenic differentiation and proliferation synergy with MAPK,BMP-2 and other pathways. In addition,NG can be combined with some inorganic biocompatible materials to form a composite material or biological membrane,which,as a novel bone repairing material,has certain clinical application prospect.

关 键 词：柚皮苷 成骨诱导 机制研究 通路研究 

分 类 号：R282.7[医药卫生—中药学]