异维A酸红霉素凝胶治疗轻中度寻常痤疮的疗效观察  

Efficacy Observation of Isotretinoin Erythromycin Gel in the Treatment of Mild-to-moderate Acne Vulgaris

作　　者：牛金茹[1] 阮晓兰[1] 

机构地区：[1]开滦总医院林西医院,河北唐山063103

出　　处：《中国药房》2016年第9期1202-1204,共3页China Pharmacy

摘　　要：目的:观察异维A酸红霉素凝胶治疗轻中度寻常痤疮的疗效和安全性。方法:120例轻中度寻常痤疮患者随机均分为观察组和对照组。观察组患者于每晚临睡前给予异维A酸红霉素凝胶适量,涂抹于患处,每日1次;对照组患者于每晚临睡前给予维胺酯维E乳膏适量,涂抹于患处,每日1次。两组患者治疗前均彻底清洁患处皮肤后使用药品,治疗期间不使用化妆品,饮食清淡忌辛辣,作息规律少熬夜。两组疗程均为2个月。观察两组患者的临床疗效,治疗前后各皮损积分、皮脂分泌率(SER)及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者各皮损积分、SER均显著低于同组治疗前,而观察组皮损数量积分、皮疹形态积分、SER均低于对照组,差异均有统计学意义(P<0.05);但皮疹类型积分两组间比较,差异无统计学意义(P>0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:异维A酸红霉素凝胶治疗轻中度寻常痤疮疗效显著,且安全性较好。OBJECTIVE：To observe the efficacy and safety of Isotretinoin erythromycin gel in the treatment of mild-to-moderate acne vulgaris. METHODS：120 patients with mild-to-moderate acne vulgaris were randomly divided into observation group and control group. Observation group was given appropriate amount of Isotretinoin erythromycin gel in affected areas every night before bed,once a day;control group was given appropriate amount of Viaminate vitamin E cream in affected areas every night before bed,once a day. The skin was thoroughly cleaned before treatment,no cosmetics and no spicy diet,rest rules and less staying up late. The treatment course for both groups was 2 months. Clinical efficacy,skin lesion scores,inflammation sebum secretion rate（SER）before and after treatment,and the incidence of adverse reactions in 2 groups were observed. RESULTS：The total effective rate in observation group was significantly higher than control group,the difference was statistically significant（P〈0.05）. after treatment,the skin lesion scores and SER in 2 groups were significantly lower than before,the number of skin lesions,rash forms and SER in observation group were significantly lower than control group,the differences were statistically significant（P〈0.05）;but there was no significant difference in the rash types between 2 groups（P〉0.05）. And there was no significant difference in the incidence of adverse reactions（P〉0.05）. CONCLUSIONS：Isotretinoin erythromycin gel has significant efficacy in the treatment of mild-to-moderate acne vulgaris,with good safety.

关 键 词：异维A酸红霉素凝胶 轻中度寻常痤疮 疗效 安全性 

分 类 号：R751[医药卫生—皮肤病学与性病学]