湿法制粒技术在连花清瘟片中的应用  

Study on the Application of Wet Granulation Technique in Lianhuaqingwen Tablets

作　　者：武景路 张丽丽[1] 

机构地区：[1]石家庄以岭药业股份有限公司,河北石家庄050035

出　　处：《亚太传统医药》2016年第6期32-33,共2页Asia-Pacific Traditional Medicine

摘　　要：目的:采用正交试验法优化连花清瘟片制备过程中的湿法制粒工艺。方法:采用湿法制粒法制备连花清瘟片颗粒,采用正交试验法考察搅拌速率、切碎速度、搅拌时间、PVP浓度对连花清瘟片颗粒水分含量、优级品率的影响。结果:最佳制粒工艺为搅拌速度为75r/min,PVP浓度为5%,搅拌时间为15s,切碎速度为650r/min。结论:该法经验证稳定可靠,重复性好,可适用于大批量生产。Objective：To optimize the use of orthogonal experiment Lianhuaqingwen film grain wet granulation molding process.Methods：Prepared using wet granulation method Lianhuaqingwen film grain,stirring rate by orthogonal design,shredding speed,mixing time,the impact of even clear water flower blast sheet particles,superior product rate of PVP concentrations.Results：The optimum granulation process conditions：stirring speed 75r/min,PVP concentration of 5%,stirring time 15 s,chopped speed650r/min.Conclusion：The method proven stable and reliable,suitable for mass production.

关 键 词：连花清瘟片 湿法制粒 水分含量 优级品率 正交试验 

分 类 号：R283[医药卫生—中药学]