脑康灵胶囊的质量标准研究  

Study on Quality Standard of Naokangling Capsules

作　　者：王婴[1] 王岩[1] 

机构地区：[1]广东药学院,广东广州510006

出　　处：《中医药导报》2016年第6期63-66,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的：建立脑康灵胶囊的质量标准。方法：采用显微鉴别法对制剂中的红花、石菖蒲、龟甲、地龙进行定性鉴别;采用TLC法对枸杞子、地龙、石菖蒲进行定性鉴别;采用HPLC法对阿魏酸进行含量测定。结果：显微鉴别和TLC法特征明显,专属性强。HPLC法测定中,阿魏酸在0.1062~0.8496μg范围内呈良好的线性关系（r=0.9999）,平均回收率为98.81%（RSD%=1.13%,n=6）。结论：本法操作简便可行、重复性好,可用于本制剂的质量控制方法。Objective： To establish a method for quality control of Naokangling capsules. Methods： Honghua（Carthami flos）, Shichangpu（Acori tatarinowii rhizome）, Guijia（Testudinis carapax et plastrum） and Dilong（Pheretima） were identified by microscopic identification; Gouqi（Lycii fructus）, Dilong（Pheretima） and Shichangpu（Acori tatarinowii rhizome） were identified by TLC; the content of ferulic acid was determined by HPLC.Results： Microscopic identification and TLC showed obvious characteristics and good specificity. The liner range of ferulic acid was 0.1062~0.8496 μg（r=0.9999）, with the average recovery of 98.81%（RSD%=1.13%, n=6）.Conclusion： The method is simple, feasible and repeatable. It can be used for quality control of Naokangling capsules.

关 键 词：脑康灵胶囊 质量标准 TLC HPLC 

分 类 号：R284[医药卫生—中药学]