硫酸沙丁胺醇鼻用原位凝胶的制备及体外释放度考察  

Preparation of Salbutamol Sulphate for Nose in situ gel and Its Release Rate in Vitro

作　　者：程荷珍[1] 杨晓艳[1] 

机构地区：[1]武汉科技大学附属天佑医院,武汉430064

出　　处：《抗感染药学》2016年第1期18-22,共5页Anti-infection Pharmacy

摘　　要：目的:制备硫酸沙丁胺醇pH敏感型鼻用凝胶,并考察其体外释放度和黏附力。方法:以卡波姆-934为凝胶基质,采用羟丙基甲基纤维素(HPMC)调节胶凝强度,并考察凝胶体外释放度、黏附力等指标,优选基质处方。结果:鼻用凝胶基质为0.5%卡波姆-934、2%HPMC,其10 h内体外释放度为98.9%,黏附力为72.1 g/cm^2。结论:优选的基质处方可用于制备硫酸沙丁胺醇pH敏感型鼻用凝胶,其质量符合要求。Objective： To prepare the salbutamol sulphate for nose in situ gel and to investigate its release and adhesion force in vitro. Methods： The gel matrix was prepared with carbopol, the gel strength was adjusted with HPMC and the release degree in vitro, the adhesion force etc. were investigated, optimizing the prescription base. Results： The nasal gel matrix was prepared with 0.5% carbopol and 2% HPMC. The release degree in vitro was 98.9% in 10 h and the adhesion force was 72.1 g/cm^2. Conclusion： The selected base can be used for the preparation salbutamol sulphate pH-sensitive nasal gel and the quality meets the requirement.

关 键 词：硫酸沙丁胺醇 卡波姆 PH敏感 鼻用凝胶 

分 类 号：R969.3[医药卫生—药理学]