微生态制剂治疗抗生素相关性腹泻临床研究  

Clinical effect of probiotics on treatment of antibiotic-associated diarrhea

作　　者：王威[1] 岳妍[1] 郝莉莉[1] 姚鹏[1] 魏景景[1] 

机构地区：[1]天津中医药大学第一附属医院脾胃科,天津300381

出　　处：《中华医院感染学杂志》2016年第6期1258-1260,共3页Chinese Journal of Nosocomiology

基　　金：国家中医药管理局基金资助项目(2013BAI02B05)

摘　　要：目的分析抗生素相关性腹泻患者应用微生态制剂双歧杆菌三联活菌胶囊治疗的临床效果,以更好的调节肠道功能,促进肠道微生态平衡。方法选取2013年7月-2015年7月医院接受治疗的抗生素相关性腹泻患者80例,随机分为观察组和对照组,每组各40例;对照组患者采用蒙脱石散治疗,观察组患者在此基础上给予双歧杆菌三联活菌胶囊治疗,对比两组患者临床治疗效果、治疗前后菌群失调情况及便培养出病原菌构成比、治疗后不良反应。结果观察组患者治疗总有效率为95.00%,明显高于对照组的70.00%,差异有统计学意义(P<0.05);治疗后观察组患者无菌群失调,对照组患者菌群失调率22.50%,治疗后观察组患者便培养出革兰阳性菌构成比高于对照组,而革兰阴性菌构成比低于对照组,差异有统计学意义(P<0.05);两组患者治疗后均未出现明显不良反应。结论抗生素相关性腹泻患者应用微生态制剂双歧杆菌三联活菌胶囊治疗的临床效果较明显,可调节患者的肠道功能,促进肠道微生态平衡,临床安全性高。OBJECTIVE To observe the clinical effect of probiotics Bifidobacteriumtriple viable capsule on treatment of patients with antibiotic-associated diarrhea so as to better regulate the intestinal function and facilitate the intestinal microecological balance.METHODS A total of 80 patients with antibiotic-associated diarrhea who were treated in the hospital from Jul 2013 to Jul 2015 were enrolled in the study and randomly divided into the observation group and the control group,with 40 cases in each group.The control group was treated with montmorillonite powder,while the observation group was treated with additional Bifidobacteriumtriple viable capsule on the basis of the treatment with montmorillonite powder.The clinical curative effects,incidence of dysbacteriosis,constituent ratios of pathogens cultured from stool specimens,and incidence of adverse reactions were observed and compared between the two groups of patients.RESULTS The total effective rate of treatment of the observation group was 95.00%,significantly higher than 70.00% of the control group（P0.05）.The incidence of dysbacteriosis was 0in the observation group after the treatment,22.50% in the control group.The constituent ratio of the gram-positive bacteria cultured from the stool specimens was higher in the observation group than in the control group after the treatment,while the constituent ratio of the gram-negative bacteria was lower in the observation group than in the control group（P0.05）.The obvious adverse reactions occurred in neither group of patients.CONCLUSIONThe probiotics Bifidobacteriumtriple viable capsule can achieve significant clinical effect on treatment of the patients with antibiotic-associated diarrhea,regulate the intestinal function,and promote the intestinal microecological balance,with the clinical safety high.

关 键 词：抗生素相关性腹泻 微生态制剂 双歧杆菌三联活菌胶囊 菌群失调 

分 类 号：R516.1[医药卫生—内科学]