慢性丙型肝炎病毒感染患者发生2型糖尿病的流行病学调查  

Epidemiological survey of chronic hepatitis C virus infection patients with type 2 diabetic mellitus

作　　者：邓舒妮[1] 张学思[2] 李新玥[3] 许碧夏[1] 罗剑静 

机构地区：[1]肇庆医学高等专科学校内科教研室,广东肇庆526020 [2]肇庆市第一人民医院科教科,广东肇庆526020 [3]肇庆医学高等专科学校中医科,广东肇庆526020

出　　处：《中华医院感染学杂志》2016年第6期1279-1280,1283,共3页Chinese Journal of Nosocomiology

基　　金：广东省卫生厅中医药科研基金资助项目(20122175)

摘　　要：目的对慢性丙型肝炎病毒患者发生2型糖尿病进行流行病学调查,为降低患者发生率提供参考依据。方法选取2015年1-8月医院诊治的444例慢性丙型肝炎感染患者,将66例慢性丙型肝炎感染发生2型糖尿病患者设置为试验组,选取378例慢性丙型肝炎感染未发生糖尿病患者为对照组,采用医院自拟问卷调查表对患者临床资料、生化指标、丙型肝炎病毒血清等指标进行统计,分析慢性丙型肝炎感染患者发生2型糖尿病的流行病学。结果 66例患者慢性丙型肝炎感染患者发生2型糖尿病中男性高于女性(P<0.05),城市患者显著高于农村患者(P<0.05),年龄段60岁以上患者显著高于其他年龄患者(P<0.05);慢性丙型肝炎感染患者2型糖尿病发生率与年龄、性别、户籍、饮酒史以及伴有脂肪肝关系密切(P<0.05);两组患者谷草转氨酶、谷丙转氨酶、碱性磷酸酶及血清白蛋白指标差异无统计学意义。结论慢性丙型肝炎感染发生2型糖尿病在中老年人、城市居民以及合并脂肪肝患者中发生率较高,应该根据危险因素及流行病学制定有效措施,降低发生率。OBJECTIVE To conduct the epidemiological survey of the chronic hepatitis C virus infection patients with type 2diabetic mellitus so as to reduce the incidence rate.METHODS A total of 444 patients with chronic hepatitis C virus infection who were treated in hospitals from Jan 2015 to Aug 2015 were enrolled in the study,then 66 chronic hepatitis C virus infection patients with type 2diabetic mellitus were assigned as the experimental group,and 378 chronic hepatitis C virus infection patients without diabetic mellitus were set as the control group.The statistical analysis of the indicators,including the clinical data,biochemical indicators,and hepatitis C virus serum,was performed by using the self-designed questionnaire,and the epidemiological characteristics of the chronic hepatitis C virus infection patients with type 2diabetic mellitus were observed.RESULTS Among the 66 chronic hepatitis C virus infection patients with the type 2diabetic mellitus,the proportion of the male patients was higher than that of the female patients（P0.05）;the proportion of the patients from urban area was higher than that of the patients from the rural area（P0.05）;the proportion of the patients aged more than 60 years old was higher than that of the patients in other age groups（P0.05）.The incidence of the type 2diabetic mellitus in the patients with chronic hepatitis C virus infection was closely associated with the age,gender,registered permanent residence,drinking history,and complication of fatty liver（P0.05）.There was no significant difference in the aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,or serum albumin between the two groups of patients.CONCLUSION Among the patients with chronic hepatitis C virus infection,the incidence rate of type 2diabetic mellitus is relatively high in the middle-aged patients,urban residents,or patients complicated with fatty liver.

关 键 词：慢性丙型肝炎 2型糖尿病 危险因素 流行病学 感染率 

分 类 号：R512.63[医药卫生—内科学]