小鼠乳腺肿瘤病毒与人乳腺癌关系的研究进展  

Progress of research on relationship between mouse mammary tumor virus and human breast cancer

作　　者：张莹[1] 任占平[1] 戴文斌[1] 杨立[1] 张芫[1] 

机构地区：[1]柳州市人民医院病理科,广西柳州545006

出　　处：《中华医院感染学杂志》2016年第6期1437-1440,共4页Chinese Journal of Nosocomiology

基　　金：广西自然科学基金资助项目(贵科自0991270)

摘　　要：小鼠乳腺肿瘤病毒(mouse mammary tumor virus,MMTV)自首次研究发现与人类乳腺癌有关联后,研究人员进行一系列研究以验证MMTV作为与乳腺癌相关的人类病原体的假设,主要从基因水平、免疫学反应、流行病学等方面研究,很多研究结果支持MMTV与人类乳腺癌存在相关,特别是在基因方面,如发现了许多MMTV整合到人DNA的位点,乳腺癌组织存在MMTV样病毒的序列等,但仍未获得具有较强说服力的直接证据,而且也有不少的研究结果是相反,因此,还要不断研究才能提供更实质证据验证MMTV在乳腺癌存在与否、及其潜在的作用。Since the mouse mammary tumor virus（MMTV）was discovered for the first time to be associated with the human breast cancer,researchers have persevered with study of the hypothesis of MMTV as a human pathogen associated with breast cancer.The main aspects of these studies included the gene level,immunological response and epidemiology.Many studies supported the view that there was relationship between the MMTV and the human breast cancer,in particular,there were many aspects of gene level evidence,for example,the finding of MMTV integration sites into DNA of human breast cancer cells,the presence of sequences resembling MMTV in patients with breast cancer,and so on.Unfortunately,strong convincing direct evidence remained absent.In addition,some of results were just the opposite.Therefore,continuous research is necessary in order to provide more substantial evidence to verify the presence or absence of MMTV,and its potential role in breast cancer.

关 键 词：小鼠 乳腺肿瘤病毒 人乳腺癌 致癌病毒 

分 类 号：R373[医药卫生—病原生物学]