脐带间充质干细胞移植对强直性脊柱炎患者免疫调节及组织损伤的影响  

Effects of umbilical cord mesenchymal stem cell transplantation on immune regulation and tissue damage in patients with ankylosing spondylitis

作　　者：汪军[1] 陈路[2] 

机构地区：[1]阆中市人民医院骨科,四川省阆中市637400 [2]川北医学院附属医院骨科,四川省南充市637000

出　　处：《中国组织工程研究》2016年第1期60-64,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:间充质干细胞具有独特的免疫调节特性,使得其成为移植领域和治疗自身性免疫疾病的研究热点。目的:探讨脐带间质干细胞对强直性脊柱炎患者免疫水平以及组织损伤的影响。方法:回顾性分析61例强直性脊柱炎患者的临床资料,按照治疗方法分为对照组(33例)和观察组(28例),分别进行免疫及生物剂治疗、脐带间充质干细胞输注治疗。治疗结束后随访12个月,观察两组治疗效果、免疫学指标、病情活动指数评分和不良反应发生情况。结果与结论:(1)总有效率:观察组和对照组分别为89%和76%,经比较差异有显著性意义(P<0.05)。(2)随访12个月,两组的血沉等指标均得到显著改善,且观察组均显著优于对照组(P<0.05);两组病情活动指数评分均随着时间的推移不断下降,且治疗后3个月开始,观察组病情活动指数评分均显著低于对照组(P<0.05)。(3)不良反应:观察组有1例患者在治疗过程中出现注射外渗现象,经重新选择血管后顺利完成注射。2例患者出现轻微发热现象,经积极物理降温之后体温恢复至正常水平。(4)结果表明,脐带间充质干细胞输注治疗强制性脊柱炎可以显著改善患者的免疫水平,并有效减轻组织损伤,不良反应较轻微。BACKGROUND： Because of unique immunomodulatory properties, mesenchymal stem cells have become a research hotspot in the field of transplantation and the treatment of immune disease. OBJECTIVE： To investigate the effect of umbilical cord mesenchymal stem cells on immune level and tissue injury in patients with ankylosing spondylitis. METHODS： The clinical data of 61 patients with ankylosing spondylitis were analyzed retrospectively, and thesepatients were divided into control group（n=33） and observation group（n=28） according to the treatment method, who were given immune and biological agents or umbilical cord mesenchymal stem cell infusion, respectively. All the patients were followed up for 12 months and at 12 months after treatment, therapeutic effect, immune level, disease activity index and adverse reactions were observed and compared between the two groups. RESULTS AND CONCLUSION： The total effective rate was 89% in the observation group and 76% in the control group, and there was a significant difference between groups. At 12 months after treatment, erythrocyte sedimentation rate and other indicators were improved in all the patients, especially in the observation group（P〈0.05）; the disease activity index scores were reduced gradually in the two groups, which were significantly lower in the observation group than the control group beginning at 3 months after treatment（P〈0.05）. In the observation group, one case presented with injection extravasation and then the injection was successfully completed after re-choice of the blood vessel; two cases had mild fever, and their temperature returned to normal after active physical cooling. These findings indicate that umbilical cord mesenchymal stem cells for ankylosing spondylitis can remarkably improve the immune level, reduce tissue damage and result in little adverse effects in patients.

关 键 词：脊柱炎 强直性 脐带 间质干细胞移植 免疫调节 组织工程 干细胞 移植 强直性脊柱炎 脐带间充质干细胞 免疫水平 病情活动指数评分 组织损伤 

分 类 号：R318[医药卫生—生物医学工程]