左氧氟沙星与奥硝唑联用致横纹肌溶解症  

Rhabdomyolysis due to application of levofloxacin and ornidazole

作　　者：齐艳霞[1] 秦玉花[1] 

机构地区：[1]河南省人民医院临床药学科,郑州450003

出　　处：《药物不良反应杂志》2016年第1期64-65,共2页Adverse Drug Reactions Journal

摘　　要：1例30岁女性患者因盆腔炎口服左氧氟沙星片（0.5 g、1次/d）和奥硝唑分散片（0.5 g、2次/d）共14 d。服药第13天患者出现四肢肌肉酸痛、乏力。停药后四肢酸痛、乏力加重。停药第12 天实验室检查示CK 939 U/L，CK-MB 41.3 U/L，LDH 313 U/L，考虑为横纹肌溶解症。嘱患者大量饮水，并给予碳酸氢钠片（0.5 g、3次/d）和辅酶Q10 片（10 mg、3次/d）口服。2周后复查，患者血清CK 96 U/L，CK-MB 21 U/L，LDH 287 U/L，肌痛、乏力症状消失。3个月后复诊，上述指标均已恢复正常。A 30-year-old female patient with pelvic inflammation received levofloxacin tablets 0.5 g once daily and ornidazole dispersible tablets 0.5 g twice daily for 14 days. On day 13 of drug use, the patient developed aching limbs and fatigue. The symptoms were worsened after drug withdrawal. Laboratory tests on day 12 after drug withdrawal showed the following values： creatine kinase（CK） 939 U/L, creatine kinase isoenzyme（CK-MB） 41.3 U/L, lactate dehydrogenase（LDH） 313 U/L. The patient was diagnosed as rhabdomyolysis. She was informed to drink plenty of water, received sodium bicarbonate tablet （0.5 g, thrice daily） and coenzyme Q10 tablet （10 mg, thrice daily）. Two weeks later, the values of CK, CK-MB, and LDH were 96 U/L, 21 U/L, and 287 U/L, respectively. Her symptoms of aching limbs and fatigue disappeared. The results of subsequent visit three months later showed that the above mentioned parameters returned to normal.

关 键 词：氧氟沙星 奥硝唑 横纹肌溶解 

分 类 号：R685.5[医药卫生—骨科学]