复方氨酚烷胺致过敏性休克  

Anaphylactic shock due to compound paracetamol and amantadine hydrochloride

作　　者：任培培[1] 付莹[1] 

机构地区：[1]沈阳市第四人民医院药剂科,110031

出　　处：《药物不良反应杂志》2016年第1期65-66,共2页Adverse Drug Reactions Journal

摘　　要：1例68岁女性患者在右眼小梁切除＋羊膜覆盖术后第2天因出现咳嗽、流涕而自行服用复方氨酚烷胺1片（每片含对乙酰氨基酚250 mg，盐酸金刚烷胺100 mg，人工牛黄10 mg，咖啡因15 mg，马来酸氯苯那敏2 mg）。服药后约30 min，患者出现头晕、恶心、呕吐，尿失禁，上肢及小腿瘙痒，面色苍白，血压80/44 mmHg（1 mmHg=0.133 kPa），脉搏90次/min。立即给予抗过敏、扩充血容量及吸氧等处理。约30 min后患者血压90/62 mmHg，2 h后头晕、恶心等症状逐渐减轻，6 h后血压106/69 mmHg。A 68-year-old female patient self-medicated with 1 tablet of compound paracetamol and amantadine hydrochloride （each tablet contained acetaminophen 250 mg, amantadine hydrochloride 100 mg, calculus bovis factitious 10 mg, caffeine 15 mg, and chlorpheniramine maleate 2 mg） because of nasal discharge and cough on the second day of trabeculectomy with covering of amniotic membrane in her right eye. About 30 minutes after administration, she developed dizziness, nausea, vomiting, urinary incontinence, itching on her arms and calves, and pale. Her blood pressure was 80/44 mmHg and heart rate was 90 beats/min. Anti-allergic treatments, blood volume expansion, and oxygen mask were given. Thirty minutes later, her blood pressure increased to 90/62 mmHg. The patient′s symptoms gradually alleviated 2 hours later and the blood pressure increased to 106/69 mmHg 6 hours later.

关 键 词：复方氨酚烷胺 过敏反应 

分 类 号：R971.1[医药卫生—药品]