左旋多巴骤然停用致撤药综合征  

Withdrawal syndrome induced by sudden stop of levodopa

作　　者：张羽钦[1] 王兰[1] 张波[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院药剂科,100730

出　　处：《药物不良反应杂志》2016年第1期70-71,共2页Adverse Drug Reactions Journal

摘　　要：1例60岁男性帕金森病患者（帕金森病史1年余）自行停用左旋多巴（0.25 g，2次/d）约3周后相继出现高热，口齿、神志不清、心率加快 （130～138次/min）、呼吸急促、谵妄伴攻击行为、肌张力增高、嗜睡、震颤加重、认知能力下降等症状，多次实验室检查示外周血白细胞计数增高（16×10^9/L～28×10^9/L）。经反复与患者家属沟通，于停药后约4周恢复服用左旋多巴（0.25 g，2次/d），恢复用药后第4天患者神志、四肢肌张力恢复正常，未再出现谵妄等精神症状，帕金森病症状缓解。A 60-year-old male with Parkinson′s disease for one year suddenly stopped using levodopa （0.25 g,twice daily） by himself. About 3 weeks later, he developed the symptoms of ardent fever, inarticulacy, confusion, increased heart rate （130-138 beats/min）, shortness of breath, delirium, aggressive behavior, hypermyotonia, drowsiness, increased tremble, and decreased cognitive ability successively. The results of laboratory test showed increased white blood cell count （16×10^9/L-28×10^9/L）. The patient agreed to resume taking levodopa （0.25 g, twice daily） about 4 weeks after drug withdrawal by conversations with his family member repeatedly. The patient′s mental ability and muscle tension of limbs returned to normal on day 4 of medication again. The symptom of delirium did not appear and the symptoms of Parkinson′s disease were relieved.

关 键 词：左旋多巴 撤药综合征 骤然停用 白细胞计数增高 肌张力增高 帕金森病 患者家属 神志不清 

分 类 号：R971[医药卫生—药品]