老年心力衰竭患者血清白细胞介素-17、白细胞介素-35水平变化  

Clinical study on changes of serum IL-17 and IL-35 levels in patients with heart failure

作　　者：吴长明 陈伟良 徐尚志 陈群 董奕裕 

机构地区：[1]浙江省荣军医院心内科,浙江省嘉兴314000 [2]武警浙江总队医院心血管内科,浙江省嘉兴314000 [3]浙江省荣军医院检验科,浙江省嘉兴314000

出　　处：《中国基层医药》2016年第4期556-560,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨血清 IL-17、IL-35在老年心力衰竭（心衰）患者中的水平变化及意义。方法选取60例心衰患者为研究对象（观察组）。将60例心衰患者按照病情程度的不同分为心衰急性期（34例）和心衰稳定期（26例）；将60例患者按照 NYHA 分级标准分为心衰Ⅱ级24例，Ⅲ级20例，Ⅳ级16例；按照原发疾病的不同分为：扩张型心肌病组（A 组，20例），冠心病组（B 组，24例），高血压心脏病组（C 组，16例）。另选择同期在该院门诊体检的健康老年人42例为对照组。统计受试者血清 IL-17、IL-35水平，并对心衰患者血清IL-17、IL-35水平进行相关性分析。结果观察组血清 IL-17水平高于对照组[（15．61±4．02）pg／mL 比（9．49±3．96）pg／mL，t ＝9．018，P ＜0．01]；观察组血清 IL-35水平明显低于对照组[（52．78±4．29）pg／mL 比（61．49±4．81）pg／mL，t ＝11．963，P ＜0．01）]。心衰急性期患者血清 IL-17水平高于心衰稳定期，差异有统计学意义（t ＝6．278，P ＜0．01）；心衰急性期患者血清 IL-35水平明显低于心衰稳定期，差异有统计学意义（t ＝9．529，P ＜0．01）；随着心衰级别的增加，血清 IL-17水平呈上升趋势，且三组间两两比较，差异均有统计学意义（F ＝6．098，P ＜0．01）；随着心衰级别的增加，血清 IL-35水平呈下降趋势，且三组间差异均有统计学意义（F ＝8．978，P ＜0．01）；A 组血清 IL-17水平高于 B 组和 C 组，差异有统计学意义（F ＝6．096，P ＜0．01），但 B组和 C 组血清 IL-17水平差异无统计学意义（t ＝0．172，P ＞0．05）；A 组血清 IL-35水平低于 B 组和 C 组，差异有统计学意义（F ＝8．978，P ＜0．01），但 B 组和 C 组血清 IL-35水平差异无统计学意义（t ＝0．208，P ＞0．05）；血清 IL-17与血清 IL-35水平呈明显负相关（r ＝－0．429，P ＝0．009）。结论IL-17在�Objective To study changes of serum IL-17 and IL-35 levels in patients with heart failure. Methods 60 patients with heart failure （observation group）were selected as research subjects.60 patients accord-ing to different severity were divided into acute period heart failure （34 cases）and stable stage heart failure （26 ca-ses）;60 patients graded according to the NYHA standards were divided into 24 cases of heart failure with grade Ⅱ, 20 cases of grade Ⅲ ,16 cases of grade Ⅳ.According to the different primary diseases ：expansion cardiomyopathy＆amp;nbsp;group （20 cases in group A）,the coronary heart disease group （group B,24 cases）,hypertensive heart disease group （group C,16 cases）.During the same period,42 healthy elderly people in our hospital were selected as control group. The serum IL-17,IL-35 levels were tested,and the serum IL-17,IL-35 levels in patients with heart failure were ana-lyzed.Results Serum level of IL-17 in the observation group was higher than the control group,and the difference was significant [（15.61 ±4.02）pg/mL vs （9.49 ±3.96）pg/mL,t =9.018,P 〈0.01].Serum level of IL-35 in the observation group was significantly lower than that of the control group,and the difference was significant[（52.78 ± 4.29）pg/mL vs （61.49 ±4.81）pg/mL,t =11.963,P 〈0.01].The level of serum IL-17 in acute stage of patients with heart failure was higher than that of stable heart failure,and the difference was significant （t =6.278,P 〈0.01）;IL-35 level in serum of patients with heart failure in acute phase was lower than that of stable heart failure,the difference was significant （t =9.529,P 〈0.01）.With the increase in heart failure grade,serum IL-17 level showed a rising trend,and the differences among three groups had statistical differences （F =6.098,P 〈0.01）;serum IL-35 level decreased,and the differences among three groups had statistical differences（F =8.978,P 〈0.01）.The serum IL-17 level of A group was higher than that in B group and C

关 键 词：心力衰竭 白细胞介素 相关性 老年人 

分 类 号：R541.6[医药卫生—心血管疾病]