他达拉非及舍曲林治疗早泄疗效差异性的系统评价  

Effect of tadalafil and seculin in treatment of premature ejaculation: System evaluation

作　　者：谢子平[1] 谭艳[1] 谢胜[1] 王万荣[1] 李韬[1] 欧阳海[1] 王澍弘[1] 康照鹏[1] 

机构地区：[1]湖北医药学院附属人民医院男科,湖北十堰442000

出　　处：《中国性科学》2016年第3期5-11,共7页Chinese Journal of Human Sexuality

摘　　要：目的:探讨他达拉非及舍曲林治疗早泄的疗效差异性。方法:通过检索自1999年1月至2014年1月期间英国医学会电子全文期刊数据库(BMA)、荷兰医学文摘数据库(EMbase)、学术期刊集成全文数据库(ASP)、考克兰图书馆(The Cochrane Library)、西文生物医学期刊文献数据库(EMCC)、美国国立医学图书馆生物医学信息检索系统(Pubmed)、万方数据库(CECDB)、维普中文科技期刊全文数据库(CQVIP)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、中国学术期刊全文数据库(CNKI)等数据库内相关的随机对照试验(RCT),对纳入文献的质量进行严格评价和资料提取,使用Stata/SE version12.0软件对纳入研究进行系统评价。结果:最终纳入9篇RCT,共542例患者,其中269例予以他达拉非、273例予以舍曲林。系统评价结果显示:经治疗60d时,相比使舍曲林,他达拉非组患者的阴道内射精潜伏时间(IELF)显著提升[WMD=0.40、95%CI=(0.05,0.74)]。且达拉非组患者对于性生活满意度显著高于舍曲林组患者[OR=1.33、95%CI=(1.01,1.77)]。但对于经治疗28d的IELF,系统评价显示两种药物未见显著差异性[WMD=-0.02、95%CI=(-0.64,0.61)]。结论:使用他达拉非治疗早泄,可提升患者经治疗60d时的IELF、提升患者的性生活满意度,疗效确切,值得临床推广。Objectives： To investigate the different curative effect of tadalafil and seculin in the treatment of premature ejaculation. Methods： By searching the RCT Pubmed,BMA,EMbase,ASP,The Cochrane Library,EMCC,CBM,CNKI,CECDB,CQVIP,VIP database from January 1999 to January 2014,strict appraisal and data extraction were done on the quality of the included studies. Stata / SE version 12 software was used for systematic evaluation of included studies. Results： Finally,9 RCT articles were included. Among 542 patients,269 cases treated with tadalafil,and 273 cases treated with sertraline were included. System evaluation results showed that after treatment for 60 days,compared with seculin group,the intravaginal ejaculation latency time（ IELF） of tadalafil group significantly increased [WMD = 0. 40,95% CI =（ 0. 05,0. 74） ]. And sexual satisfaction of tadalafil group was significantly higher than that in p seculin group [P = 0. 289,sertraline group I2 = 0%,OR = 1. 33,95% CI =（ 1. 01,1. 77） ]. But for the treatment of IELF 28,the system evaluation showed no significant differences between two kinds of drugs [WMD =- 0. 02,95% CI =（- 0. 64,0. 61） ]. Conclusions： The use of tadalafil in the treatment of premature ejaculation can improve the IELF after treatment for 60 days and improve the patient＇s sexual satisfaction with curative effect,which is worth clinical promotion.

关 键 词：他达拉非 舍曲林 早泄 

分 类 号：R698[医药卫生—泌尿科学]