曲普瑞林对特发性中枢性性早熟女童治疗作用的自身前后对照观察  

Contrast observation of before and after triptorelin treatment of the idiopathic precocious puberty( ICPP) girls

作　　者：汪培欢[1] 施弦[2] 

机构地区：[1]湖州市中心医院药学部,浙江湖州313000 [2]湖州市中心医院儿科,浙江湖州313000

出　　处：《中国性科学》2016年第3期59-62,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨曲普瑞林治疗特发性中枢性性早熟(ICPP)女童的临床疗效。方法:将2011年1月至2013年1月我院收治的124例ICPP女童随机分为观察组与对照组,每组62例。观察组患儿给予曲普瑞林治疗,对照组患儿不予特殊治疗,两组患儿均随访2年,比较两组患儿随访过程中进行的体质量指数(BMI)、骨龄与生活年龄比值(BA/CA)、预测成年身高(PAH)、身高年龄对骨龄的追赶(Ht SDSBA)以及治疗前后和随访前后的子宫和卵巢的大小变化情况、GnRH激发试验及药物不良反应情况等。结果:观察组患儿使用曲普瑞林后的BMI指数、BA/CA、Ht SDSBA、PAH、子宫、卵巢体积、P-LH和P-FSH分别与使用前相比改变较为明显,差异有统计学意义(t=26.565,10.219,2.975,11.651,3.965,4.270,14.529,27.561,P<0.05);而未经特殊治疗的对照组ICPP患儿在随访过程中BA/CA升高及Ht SDSBA减小明显,比较差异有统计学意义(t=26.997,1.981,P均<0.05),BMI指数和PAH变化不明显,差异无统计学意义(t=1.462,0.137,P均>0.05),子宫、卵巢容积也均有不同程度的增大,GnRH激发试验峰值升高,比较差异有统计学意义(t=1.704,1.810,1.665,4.001,P均<0.05);观察组患儿治疗期间未见不良反应,且治疗过程中出现月经初潮的女童症状均消失,而对照组患儿出现月经初潮的女童的数量有所波动,但波动幅度不明显,且症状未见好转。结论:曲普瑞林治疗ICPP能有效地抑制下丘脑-垂体-性腺轴及性征发育,延缓BA成熟的临床疗效,改善成年终身高,值得在临床上推广。Objectives： To explore the clinical efficacy of triptorelin treatment on the idiopathic precocious puberty（ ICPP） girls. Methods： 124 girls with ICPP in our hospital from January 2011 to January 2013 were randomly divided into observation group and control group,62 cases in each group. The observation group was treated with triptorelin,and the control group was not treated,and the two groups were followed up for 2 years. The BMI index,BA / CA,PAH,Ht SDSBA,changes of the size of the uterus,GnRH test and adverse drug reactions in the process of the follow- up of the two groups were compared. Results： The BMI index,BA / CA,PAH,Ht SDSBA,changes of the size of the uterus and ovarian,P- LH and P- FSH after treatment of observation group changed more significantly than these before treatment,with statistically significant difference（ t = 26. 565,10. 219,2. 975,11. 651,3. 965,4. 270,14. 529,27. 561,P〈0. 05）; and BA / CA and Ht SDSBA of control group girls without special treatment changed more significantly in the process of follow- up,with statistically significant difference（ t = 26. 997,1. 981,P〈0. 05）,but the BMI index and PAH didn＇t change significantly,with no statistically significant difference（ t = 1. 462,0. 137,P〉0. 05）,the size of the uterus and ovarian,the peak of GnRH test changed more significantly（ t = 1. 704,1. 810,1. 665,4. 001,P〈0. 05）; there was no adverse reactions of the observation group during the treatment,and the menstruation symptoms of the girls disappeared during the treatment; the number of the control group who have menstruation didn＇t changed significantly. Conclusions： Triptorelin in treatment of the idiopathic precocious puberty（ ICPP） girls has good clinical curative effect,which is worth popularizing in clinic.

关 键 词：曲普瑞林 特发性中枢性性早熟 临床疗效 

分 类 号：R725[医药卫生—儿科]