超声下未成熟卵泡抽吸术对多囊卵巢患者体外受精治疗的影响  

Effect of ultrasound- guided immature follicle aspiration on the in vitro fertilization treatment of patients with polycystic ovarian syndrome

作　　者：戚静宜[1] 牛吉峰[1] 刘格琳[1] 王芳[1] 

机构地区：[1]郑州大学附属洛阳中心医院生殖医学科,河南洛阳471000

出　　处：《中国性科学》2016年第3期104-106,共3页Chinese Journal of Human Sexuality

基　　金：河南省洛阳市科技发展计划项目(1101050A)

摘　　要：目的:探讨超声下未成熟卵泡抽吸术(IMFA)对行体外受精-胚胎移植治疗的多囊卵巢综合征(PCOS)患者治疗结局改善的有效性。方法:将在我院生殖医学科行体外受精治疗的66例PCOS患者随机分成两组,实验组30例在口服避孕药期间进行IMFA预处理,对照组36例仅口服避孕药治疗。比较随后的超促排卵治疗中两组患者卵巢反应性及治疗结局的改变。结果:与对照组相比较,穿刺组在超促排卵治疗中Gn使用天数、总量、扳机日雌二醇水平明显降低,P<0.05。IMFA组未发生一例中重度OHSS,因OHSS高风险取消新鲜周期胚胎移植率也明显降低,但差异不显著P>0.05。IMFA组的胚胎种植率、流产率较对照组无统计学差异,P>0.05。结论:患者在行体外受精治疗前进行IMFA预处理可以有效改善卵巢反应性及治疗结局。Objectives： To assess the effects of ultrasound- guided immature follicle aspiration on the in vitro fertilization treatment of patients with polycystic ovarian syndrome. Methods： 66 patients with PCOS in our reproductive medicine center who received in vitro fertilization（ IVF） treatment were randomly divided into two groups. 30 cases of IMFA group during the period of oral contraceptives were treated with IMFA. 36 cases of the control group only received oral contraceptive treatment. Reactivity and treatment outcome of the two groups were compared. Results： Compared with control group,super ovulation of Gn use in total amount,number of days,the estradiol level in IMFA group decreased significantly,P〈0. 05. The IMFA group did not had severe OHSS case,because of high OHSS risk,canceling fresh embryo transfer cycles were also lower with no significant difference.Embryo implantation rate and abortion rate of IMFA group was higher than that of control group,without significant difference,P〉0. 05. Conclusions： IMFA pretreatment can effectively improve the ovarian response and treatment outcome of PCOS patients undergoing in vitro fertilization.

关 键 词：多囊卵巢综合症 未成熟卵泡抽吸 体外授精 

分 类 号：R711.6[医药卫生—妇产科学]