应用秩和比法综合评价几种促透剂的效果  

Evaluation of promoting effect of several transdermal enhancers with RSR

作　　者：恽昊 肖海容[1] 邓春燕[1] 王爱娟[1] 王晖[1] 

机构地区：[1]广东药学院中药学院,广东广州510006

出　　处：《广东药学院学报》2016年第1期61-65,共5页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省人才培养模式创新实验区([粤教高函[2014]97号])资助项目

摘　　要：目的探讨基于秩和比(RSR)值的秩和比法在透皮吸收促进剂促透效果综合评价中的应用。方法研究1%冰片、1%氮酮、1%薄荷醇、1%冰片+1%氮酮、1%薄荷醇+1%氮酮和1%冰片+1%氮酮+1%薄荷醇对模型药物双氯芬酸钠在雌性SD大鼠的离体背部皮肤进行透皮实验,计算滞后时间、渗透系数、稳态流量和增渗倍数,利用秩和比法的RSR值综合评价促透效果。结果 1%冰片+1%氮酮+1%薄荷醇和1%薄荷醇+1%氮酮组对双氯芬酸钠的促透效果最好,1%冰片+1%氮酮、1%薄荷醇和1%氮酮次之,1%冰片最差。结论基于RSR值的秩和比法可作为促透剂科学、客观评价的一种新方法。Objective To investigate the application of RSR in evaluating the promoting effect of transdermal enhancers. Methods Diclofenac sodium was used as drug mode. 1% borneolum,1% azone,1% menthol,1% borneolum＋ 1% azone,1% menthol＋ 1% azone and 1% borneolum＋ 1% azone＋ 1% menthol were used as transdermal enhancers. Transdermal absorption experiment of diclofenac sodium was detected on the device of penetrating skins of rat in vitro and lag time,penetrating rates,steady fluxes and enhancement ratio were calculated to evaluate the promoting effect of transdermal enhancers with RSR. Results The promoting effect on diclofenac sodium showed that 1% borneolum＋ 1% azone＋ 1% menthol and 1% menthol＋ 1% azone were the best. The function drops slightly with 1% azone＋ 1% borneolum,1% menthol and 1%azone ranked behind. The worst was 1% borneolum. Conclusion The promoting effect of transdermal enhancers could be objectively evaluated by RSR.

关 键 词：秩和比法 促透剂 促透效果 

分 类 号：R965[医药卫生—药理学]