头孢吡肟相关性腹泻案例分析  

Case Report:Cefepime Induced Antibiotic Associated Diarrhea

作　　者：潘蕾[1] 刘玉娟[1] 蒋淼[2] 方忠宏[1] 

机构地区：[1]复旦大学附属金山医院药剂科,上海201508 [2]复旦大学附属金山医院消化内科,上海201508

出　　处：《中国医院用药评价与分析》2016年第2期248-250,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的：探讨抗菌药物相关性腹泻（antibiotic associated diarrhea,AAD）的发病原因和治疗方法,为临床治疗提供借鉴,供临床药师学习。方法：介绍临床药师参与1例特点显著、具有学习意义的头孢吡肟相关性腹泻患者的治疗过程,并结合患者的重点临床资料以及病情变化的显著特点进行分析与总结。结果：经调整用药方案,仅24 h后患者的腹痛、体温、血常规等指标即明显好转;仅治疗5 d,患者的血常规白细胞计数为11.87×10^9/L,中性粒细胞百分比为73.91%。结论：临床对AAD应尽早发现,尽早调整治疗方案,对提高医疗质量有重大影响,其临床急症表现会快速转危为安,建议临床在进行抗感染治疗时予以重视。OBJECTIVE： To probe into the pathogenesis and treatment regimen of antibiotic associated diarrhea（ AAD）,so as to provide reference for the clinical treatment and experience for the clinical pharmacists.METHODS：To introduce the treatment process of one significant case with AAD participated by the clinical pharmacists through summarizing and analyzing the essential clinical data and distinctive features of condition changes.RESULTS： After the adjustment of medication regimen,the patient＇s abdominal pain relieved,body temperature dropped and white cell counts recovered after only 24 hours.After treatment of 5 d,the routine blood leukocyte count was 11.87 ×10~9/L,ratio of neutrophile granulocyte was 73.91%.CONCLUSIONS： The clinic should identify AAD as early as possible and adjust treatment regimen timely,which can improve the quality of medical care; and the clinical emergency could turn the corner rapidly.It is suggested that the clinic should attach more importance to the anti-infective therapy.

关 键 词：头孢吡肟 抗菌药物相关性腹泻 艰难梭菌 

分 类 号：R969.3[医药卫生—药理学]