腺性膀胱炎及膀胱癌中livin和caspase-9的表达  

Expression of Livin and Caspase-9 in Cystitis Glandularis and Bladder Carcinoma and their Clinical Significance

作　　者：丁德鑫[1] 陈辉[1] 王志[1] 杨巍[1] 乔忠杰[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院泌尿外科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2016年第6期1076-1078,1179,共4页Progress in Modern Biomedicine

基　　金：黑龙江省卫生计生委科研课题(2014-370)

摘　　要：目的：研究在腺行膀胱炎（cystitis glandularis,CG）以及膀胱癌（bladder carcinoma,BC）中livin和caspase-9的表达,探讨腺性膀胱炎与膀胱癌可能存在的关系。方法：收集哈尔滨医科大学附属第三医院2014年1月~2014年10月住院患者60例组织石蜡标本,应用SP（streptavidin-perosidase）法检测livin和caspase-9在腺性膀胱炎组织（30例）、膀胱癌组织（30例）和正常组织（30例）中的表达。结果：正常膀胱、CG和BC组织中livin阳性表达率分别为0/30,9/30（30%）和14/30（46.67%）,差异有统计学意义（P〈0.05）;caspase-9在正常膀胱、CG和BC组织中的阳性表达率分别20/30（66.67%）,15/30（50%）,3/30（10%）,差异有统计学意义（P〈0.05）。结论：腺性膀胱炎可能是正常膀胱组织向膀胱腺癌发展的一个中间阶段,在CG向BC发展过程中livin和caspase-9的异常表达具有普遍性,临床上应积极治疗并密切随访,并可将livin和caspase-9作为诊断早期膀胱癌的检测指标。Objective：To investigate the expressions of livin and caspase-9 in cystitis glandularis（CG） tissue and bladder carcinoma（BC） and their clinical significance,to explore cystitis glandularis and bladder carcinoma relationship.Methods：60 patients hospitalized tissue paraffin were collected in the Third Affiliated Hospital of Harbin Medical University from January 2014 to October2014.The expressions of livin and caspase-9 in 30 CG cases,30 BC cases and 30 cases of normal tissues were determined by streptavidin-peroxidase immunohistochemical method.Results：The positive expression rates of livin were 0/30,9/30（30 %） and 14/30（46.67 %）,the difference was statistically significant（P 0.05）;the positive expression of caspase-9 were 20/30（66.67 %）,15 /30（50%）,3/30（10 %）,the difference was statistically significant（P 0.05）.Conclusions：Cystitis glandularis may be a pre-malignant lesion in bladder,the CG patients with livin-positive and caspase-9-positive expression should need a regular followed-up for early detection of bladder cancer.

关 键 词：LIVIN CASPASE-9 腺性膀胱炎 膀胱癌 

分 类 号：R694[医药卫生—泌尿科学] R737.14[医药卫生—外科学]