AcSDKP对器官产纤维细胞功能的影响  

Effects of N-acetyl-seryl-aspartyl-lysyl-proline on Fibrogenic Cells of Different Organs

作　　者：王晶[1] 丁永年[2] 周达[1] 何玲楠 陈源文[1] 

机构地区：[1]上海交通大学医学院附属新华医院,上海200092 [2]新疆医科大学第二附属医院,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2016年第6期1161-1163,1160,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81170410;81260081);上海市卫生系统优秀青年人才培养计划项目(XYQ2011010);新疆维吾尔自治区高校科研计划重点项目(XJEDU2012I001)

摘　　要：N-乙酰基-丝氨酰-天冬氨酰-赖氨酰-脯氨酸(N-acetyl-seryl-aspartyl-lysyl-proline,AcSDKP)是广泛存在于哺乳动物体内的乙酰化小分子四肽,具有广泛的生理功能。近年来,AcSDKP参与组织器官细胞外基质沉积和纤维化调控的作用与机制越来越受到国内外学者的重视,已有研究发现其对心、肝、肺、肾等器官纤维化有抑制作用,而这些作用与各器官的产纤维细胞关系密切。本文就AcSDKP对心、肝、肺、肾内的产纤维细胞功能影响的研究进展展开综述。N-acetyl-seryl-aspartyl-lysyl-proline（N-acetyl-seryl-aspartyl-lysyl-proline,AcSDKP）,an acetylated small molecule tetrapeptide with broad physiological functions,is widespread in the mammalian.In recent years,the essential role and mechanism of AcSDKP in regulation of extracellular matrix deposition continues to gain attention in the field of tissue and organ fibrosis.It is found that AcSDKP has an anti-fibrotic effect in the heart,liver,lung and kidney,etc,and this effect is closely related to the fibrogenic cells in these tissues or organs,mainly residential fibroblasts.The effects of AcSDKP on these fibrogenic cells will be reviewed in this paper.

关 键 词：N-乙酰基-丝氨酰-天冬氨酰-赖氨酰-脯氨酸 四肽 成纤维细胞 

分 类 号：Q593[生物学—生物化学] Q591