白介素-4和免疫球蛋白E含量监测在药物过敏反应诊断中的应用价值  

Value of interleukin 4 and immunoglobulin E levels monitoring in diagnosis of drug allergy reaction

作　　者：李志勇[1] 吴杨玲[2] 蔡韶滨[3] 

机构地区：[1]厦门大学附属第一医院检验科,福建厦门361000 [2]厦门大学附属第一医院急诊部,福建厦门361000 [3]漳州卫生职业学院护理系,福建漳州363000

出　　处：《中国生化药物杂志》2015年第11期30-32,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探究白介素-4和免疫球蛋白E含量监测在药物过敏反应诊断中的应用价值。方法采用静脉注射及常规腹腔注射的方式,将0.9%Na Cl、马血清等相应的药剂进行致敏,并在不同的时间记录豚鼠血清中的白介素-4和总免疫球蛋白E指标。结果注射0.9%Na Cl与喘可治注射液,白介素-4和总免疫球蛋白E差异无统计学意义,但在其他药物致敏d8、d14和d21时,白介素-4和总免疫球蛋白E含量显著升高,均出现过敏反应。结论白介素-4和免疫球蛋白E含量指标检测是诊断药物过敏的一种有效、快速的方式。Objective To explore interleukin 4 and immunoglobulin E levels indicators monitoring value in diagnosis of drug allergy reaction.Methods The way of intravenous injection and conventional intraperitoneal injection was used,with the corresponding drugs such as saline,horse serum sensitized,and in different time interleukin- 4 and total immunoglobulin E index were recorded in guinea pig serum. Results Injection of saline and Chuankezhi injection,interleukin-4 and total immunoglobulin E protein content,the difference was not statistically significant,but in other drug induced sensitive D8, D14 and D21, interleukin-4 and total immunoglobulin E protein content increased significantly. Conclusion Interleukin 4 and immunoglobulin E levels index detection is the diagnosis of drug allergy is an effective and fast way.

关 键 词：白介素-4 免疫球蛋白E 药物过敏反应 

分 类 号：R917[医药卫生—药物分析学]