复方牛胎肝提取物联合抗病毒治疗对肝硬化患者肝纤维化指标的影响分析  

Effect of compound fetal bovine liver extract combined with anti-viral effects on liver fibrosis in patients with cirrhosis treatment

作　　者：王牡丹[1] 曹海军[2] 李善高[2] 朱灵[2] 郑健豪 

机构地区：[1]浙江省中医院急救创伤中心,浙江杭州310018 [2]浙江省中医院消化内科,浙江杭州310018

出　　处：《中国生化药物杂志》2015年第11期147-148,151,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的观察复方牛胎肝提取物联合抗病毒治疗对肝硬化患者肝纤维化指标的影响。方法选取2014年4月至2015年7月收治疗的确诊为肝硬化患者的患者共60例,按随机数字表发分为治疗组和对照组各30例,治疗组患者术后在常规抗病毒治疗的基础上给予复方牛胎肝提取物治疗,对照组术后给予常规抗病毒治疗,随访并记录2组患者血清肝纤维化指标、肝纤维化指标变化情况,采用统计学方法对数据进行分析。结果治疗1月后,治疗组血清肝纤维化指标HA、PCM值分别为(107.5±17.8、99.8±14.9)ng/m L,均低于对照组(138.4±15.2、124.1±18.1)ng/m L(P<0.05)。治疗1月后,治疗组肝纤维化指标Ⅳ型胶原、Ⅲ型前胶原值分别为(58.9±11.0、109.2±11.1)μg/L,均低于对照组(85.7±11.2、122.7±11.3)μg/L(P<0.05)。结论复方牛胎肝提取物联合抗病毒治疗对肝硬化患者肝纤维化指标的影响效果良好,优于单独运用抗病毒药物。Objective To observe the effect of compound fetal liver extract combined with antiviral therapy on liver fibrosis in patients with cirrhosis. Methods 60 patients with liver cirrhosis from April 2014 to July 2015 were randomly divided into treatment group and control group（ n = 30）. The patients in control group were treated with conventional anti viral therapy,30 cases in treatment group were treated with compound fetal liver extract combined with antiviral therapy postoperative. Results 1 month after treatment,the treatment group serum liver fibrosis HA,PCM value respectively（ 107. 5 ± 17. 8,99. 8 ± 14. 9） ng / m L,were lower than in the control group（ 138. 4 ± 15. 2,124. 1 ± 18. 1） ng / m L（ P〈0. 05）. 1 month after treatment,the treatment group liver fibrosis collagen type IV,III procollagen value respectively（ 58. 9 ± 11. 0,109. 2 ± 11. 1） μg / L,were lower than in the control group（ 85. 7 ± 11. 2,122. 7 ± 11. 3） μg / L（ P〈0. 05）. Conclusion Compound fetal bovine liver extract combined with anti- viral therapy in patients with cirrhosis has good,better than the use of antiviral drugs alone.

关 键 词：复方牛胎肝提取物 抗病毒治疗 肝硬化 肝纤维化 

分 类 号：R512.62[医药卫生—内科学]