红花注射液预防下肢骨折术后深静脉血栓形成的临床效果及其对患者血液流变学的影响  

Clinical effect of honghua injection on hemorrheology in the prevention of deep venous thrombosis after operation of lower limb fracture

作　　者：杨亚勇[1] 牟静[2] 金辉[3] 

机构地区：[1]泸州市人民医院药剂科,四川泸州646000 [2]泸州市人民医院康复医学科,四川泸州646000 [3]昆明医科大学,云南昆明650500

出　　处：《中国生化药物杂志》2015年第12期64-66,69,共4页Chinese Journal of Biochemical Pharmaceutics

基　　金：国家自然科学基金项目(30960377)

摘　　要：目的探讨红花注射液预防下肢骨折术后深静脉血栓(DVT)形成的临床效果观察及对患者血液流变学的影响。方法将2013年1月至2014年10月间收治的100例下肢骨折术后患者,采用随机数字表法随机分为对照组(n=50)和观察组(n=50)。常规治疗基础上,对照组给予利伐沙班10 mg/d治疗,观察组在对照组的基础上再加用红花注射液30 m L静脉滴注。观察比较2组患者DVT发生率、促炎因子水平、血液流变学情况及不良反应发生情况。结果观察组DVT的发生率为10.0%,明显低于对照组28.0%的DVT发生率(P<0.05)。与对照组相比,观察组术后3 d促炎因子TNF-α、IL-6和IL-8水平显著下降,且治疗后血液流变学指标红细胞压积、全血黏度和纤维蛋白原显著降低(均P<0.05)。治疗过程中,均未出现严重不良反应,组间不良反应发生率比较差异无统计学意义。结论红花注射液联合利伐沙班可以有效预防下肢骨折术后DVT发生,明显降低DVT的发生率,减轻炎性反应并改善血液高凝状态,且不良反应轻微。Objective To investigate the clinical effect of honghua injection on hemorrheology in the prevention of deep venous thrombosis（ DVT）after operation of lower limbs fractures. Methods 100 cases with operation of lower limb fracture meeting the inclusion critera were randomly divided into two groups equally. Besides conventional treatment,the control group was treated with rivaroxaban,while the observation group was treated with honghua injection and rivaroxaban. The incidence of DVT,pro-inflammatory factors,hemorheology indices and adverse reactions were observed and compared.Results The observation group had a total DVT incidence of 10. 0%,which was statistically lower than that of 28. 0% in the control group（ P〈0. 05）.Three days after the operation,pro-inflammatory factors of TNF-α,IL-6 and IL-8 in the observation group was respectively statistically lower than that in the control group（ P〈0. 05）. As to hemorheology indices,in comparison with the control group,hematocrit,whole blood viscosity and fibrinogen in the observation group were statistically lower（ P〈0. 05）. During the treatment,there were no case of severe adverse reactions,and the incidence of adverse reactions in the two groups were statistically same. Conclusion Treatment of honghua injection in combination with rivaroxaban in the prevention of DVT is reliable,which could significantly reduce the incidence of DVT,alleviate inflammatory reaction and improve blood hypercoagulable state with minor adverse reactions.

关 键 词：红花注射液 利伐沙班 下肢骨折 深静脉血栓 IL-6 血液流变学 

分 类 号：R259[医药卫生—中西医结合]