沙丁胺醇联合无创呼吸机对慢性阻塞性肺病合并呼吸衰竭患者TNF-α、IL-6、IL-8及血清CK-MB活性影响研究  

Study on the effect of salbutamol combined with noninvasive ventilator on TNF-α,IL-6,IL-8 and serum CK-MB activity in patients with chronic obstructive pulmonary disease with respiratory failure

作　　者：林贻照 王芳[1,2] 张荣照[1] 魏松青 

机构地区：[1]福建中医药大学附属康复医院呼吸科,福建福州350003 [2]福建省康复技术重点实验室,福建福州350003

出　　处：《中国生化药物杂志》2015年第12期136-138,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨沙丁胺醇联合无创呼吸机对慢性阻塞性肺病合并呼吸衰竭患者TNF-α、IL-6、IL-8及血清CK-MB活性的影响。方法收集慢性阻塞性肺病合并呼吸衰竭患者60例,随机分为对照组和实验组,每组各30例,对照组患者给予无创呼吸机治疗,实验组在对照组基础上给予沙丁胺醇治疗,治疗结束后,对所有患者的血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8,IL-8)水平及血清肌酸激酶同工酶(creatine kinase isoenzyme,CK-MB)活性进行检测。结果治疗后,与对照组比较,实验组患者的血清TNF-α水平较低,差异具有统计学意义(P<0.05);实验组患者的血清IL-6、IL-8水平较低(P<0.05);实验组患者的血清CK-MB活性较低(P<0.05)。结论沙丁胺醇联合无创呼吸机能够显著降低慢性阻塞性肺病合并呼吸衰竭患者血清TNF-α、IL-6、IL-8水平及血清CK-MB活性,减轻炎症反应,减少心肌损害。Objective To analysis the effect of salbutamol combined with noninvasive ventilator on TNF-α,IL-6,IL-8 and serum CK-MB activity in patients with chronic obstructive pulmonary disease with respiratory failure. Methods 60 patients who were diagnosed with chronic obstructive pulmonary disease with respiratory failure were collected. All patients were randomly divided into experimental group and control group,30 cases in each group.Patients in the control group received noninvasive ventilator treatment,patients in the experimental group were given salbutamol treatment on the basis of control group treatment,after the treatment,the serum levels of TNF-α,IL-6,IL-8 and serum CK-MB activity were detected in all patients. Results After treatment,compared with control group,the serum level of TNFαwas lower in the experimental group,and the difference was statistically significant（ P〈0. 05）; the serum level of IL-6 and IL-8 were lower in the experimental group（ P〈0. 05）; the serum CK-MB activity was lower in the experimental group（ P〈0. 05）. Conclusion The salbutamol combined with noninvasive ventilator can significantly reduce the serum levels of TNF-α,IL-6,IL-8 and serum CK-MB activity in patients with chronic obstructive pulmonary disease with respiratory failure,reduce the inflammatory reaction and reduce the myocardial damage,and have a guiding significance for clinica.

关 键 词：沙丁胺醇 无创呼吸机 慢性阻塞性肺病合并呼吸衰竭 TNF-Α IL-6 IL-8 CK-MB 

分 类 号：R259[医药卫生—中西医结合]