阿托伐他汀联合神经内分泌拮抗剂治疗慢性心衰的疗效观察  

Efficacy of atorvastatin combined with neuroendocrine antagonist in chronic heart failure

作　　者：施中平[1] 林加锋[2] 

机构地区：[1]温州医科大学定理临床学院心内科,浙江温州325000 [2]温州医科大学附属第二医院心内科,浙江温州325000

出　　处：《中国生化药物杂志》2015年第12期143-144,147,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的观察研究阿托伐他汀联合神经内分泌拮抗剂治疗慢性心衰的临床疗效。方法选取温州医科大学定理临床学院心内科2014年3月~2015年3月收治疗慢性心衰的患者共70例,按随机数字表法分为观察组和对照组各35例,对照组给予神经内分泌拮抗剂治疗,观察组给予阿托伐他汀联合神经内分泌拮抗剂治疗,记录2组患者相关指标变化情况。结果观察组患者治疗后脑利钠钛前体（aminoterminal pro-brain natriuretic peptide,NT-Pro BNP）和射血分数分别为[（1264.7±174.6）pg/m L、（0.58±0.07）分],均优于对照组[（2106.5±164.8）pg/m L、（0.49±0.08）]（P〈0.05）;观察组治疗后总有效率为91.43%,高于对照组71.43%（P〈0.05）。结论阿托伐他汀联合神经内分泌拮抗剂治疗慢性心衰的临床治疗效果确切,无明显副反应。Objective To observe the clinical efficacy of atorvastatin combined with neuroendocrine antagonist in the treatment of chronic heart failure. Methods 70 patients of Wenzhou Medical College Theorem Clinical College of Cardiology Department from March 2014 to March 2015 were randomly divided into observation group and control group of 35 cases in each group. The control group were given the neuroendocrine antagonist,observation group were given atorvastatin combined with neuroendocrine antagonist treatment. The changes of related indicators were recorded.Results The aminoterminal pro-brain natriuretic peptide（ NT-Pro BNP） and ejection fraction in observation group were [（ 1264. 7 ± 174. 6） pg / m L,（ 0. 58 ± 0. 07） ],which were higher than those in control group [（ 2106. 5 ± 164. 8） pg/m L,（ 0. 49 ± 0. 08） ]（ P〈0. 05）. The total effective rate in observation group was 91. 43%,which was higher than 71. 43% in control group（ P〈0. 05）. Conclusion Atorvastatin joint neuroendocrine antagonist in treatment of chronic heart failure has clinical exact effect with no significant side effects.

关 键 词：阿托伐他汀 神经内分泌拮抗剂 慢性心衰 联合用药 

分 类 号：R541.6[医药卫生—心血管疾病]