胞外信号调控激酶(ERK)信号通路与抑郁症  

Extracellular Signal Regulated Kinase(ERK) Signaling Pathway and Depression

作　　者：李牧函 余冰颖[1,3] 刘屏[1] 

机构地区：[1]解放军总医院临床药理研究室 [2]北京中医药大学 [3]河北北方学院

出　　处：《神经药理学报》2015年第1期38-44,共7页Acta Neuropharmacologica

基　　金：国家自然科学基金资助(No.81173430)

摘　　要：胞外信号调控激酶(extracellular signal-regulated kinase,ERK)信号通路对神经细胞的生长、增殖、分化和存活起关键调节作用,并且对脑内突触可塑性和学习记忆有重要影响,因此ERK信号通路逐渐成为抗抑郁机制的研究热点。该文综述了近年来ERK信号通路在抑郁症发生和治疗方面的作用和机制,供同行参考。The extracellular signal regulated kinase（ERK） signal pathway plays a key role in the growth,proliferation,differentiation and survival of neurons and has important effects on synaptic plasticity and learning and memory in the brain. Therefore,ERK signaling pathway has become a hot research topic in the research of anti-depression mechanism. This paper reviews the role and mechanism of ERK signaling pathway in the pathogenesis and treatment of depression in recent years.

关 键 词：胞外信号调控激酶(ERK) 信号通路 抑郁症 

分 类 号：R964[医药卫生—药理学]