Measurement of trace element content in bone samples using long-lived neutron activation products and high-resolution gamma-ray spectrometry  

作　　者：Vladimir Zaichick Sofia Zaichick 

机构地区：[1]Radionuclide Diagnostics Department, Medical Radiological Research Centre [2]Department of Medicine, University of Illinois, College of Medicine at Chicago

出　　处：《Nuclear Science and Techniques》2016年第1期21-28,共8页核技术（英文）

摘　　要：A nondestructive instrumental neutron activation analysis with high-resolution gamma-ray spectrometry of long-lived radionuclides was developed and used for measurement of trace element contents in samples of bone to determine health and diseases. Using this method, the silver(Ag), cobalt(Co), chromium(Cr), iron(Fe), mercury(Hg), rubidium(Rb), antimony(Sb), selenium(Se), and zinc(Zn) mass fractions were estimated in bone samples from 27 patients with intact bone(12 females and 15 males, aged from 16 to 49 years) who had died from various non-bone-related causes, mainly unexpected traumas,and from 5 patients with chondroma(2 females and 3males, 15–42 years old), obtained from open biopsies or after operation. The reliability of the differences in the results between intact bone and bone affected by chondroma was evaluated by a parametric Student's t test and a nonparametric Mann–Whitney U test. It was found that in the bone affected by chondroma, the mean mass fractions of Co, Cr, Fe, Se, Sb, and Zn were significantly higher than in normal bone tissues. In the neoplastic bone, many correlations between trace elements found in the control group were no longer evident. This work revealed that there is asignificant disturbance of the trace element metabolism in bone affected by chondroma.A nondestructive instrumental neutron activa- tion analysis with high-resolution gamma-ray spectrometry of long-lived radionuclides was developed and used for measurement of trace element contents in samples of bone to determine health and diseases. Using this method, the silver （Ag）, cobalt （Co）, chromium （Cr）, iron （Fe）, mercury （Hg）, rubidium （Rb）, antimony （Sb）, selenium （Se）, and zinc （Zn） mass fractions were estimated in bone samples from 27 patients with intact bone （12 females and 15 males, aged from 16 to 49 years） who had died from var- ious non-bone-related causes, mainly unexpected traumas, and from 5 patients with chondroma （2 females and 3 males, 15-42 years old）, obtained from open biopsies or after operation. The reliability of the differences in the results between intact bone and bone affected by chon- droma was evaluated by a parametric Student＇s t test and a nonparametric Mann-Whitney U test. It was found that in the bone affected by chondroma, the mean mass fractions of Co, Cr, Fe, Se, Sb, and Zn were significantly higher than in normal bone tissues. In the neoplastic bone, many cor- relations between trace elements found in the control group were no longer evident. This work revealed that there is a significant disturbance of the trace element metabolism in bone affected by chondroma.

关 键 词：微量元素含量 高分辨率 中子活化 长寿命 Γ能谱法 活化产物 样品 测定 

分 类 号：TL81[核科学技术—核技术及应用]