基于灰理论联合多元分析法的癌性纳差方剂组方分析及新方发现  

Analysis on traditional Chinese medicine prescriptions treating cancer-related anorexia syndrome based on grey system theory combined with multivariate analysis method and discovery of new prescriptions

作　　者：谌松霖 陈聪[2] 朱慧[3] 李敬[3] 庞雁[3,4] 

机构地区：[1]天津中医药大学研究生院,天津300193 [2]江西中医药大学,江西南昌330006 [3]天津市人民医院肿瘤科,天津300121 [4]天津中西医结合肿瘤研究所,天津300121

出　　处：《中国中药杂志》2016年第2期314-320,共7页China Journal of Chinese Materia Medica

基　　金：江西省研究生创新专项资金项目(YC2015-S356);天津中医药大学中西医结合学院研究生教育校外创新实践基地科技创新基金项目(ZXYCX201510)

摘　　要：癌性纳差是目前肿瘤疾病死亡常见原因之一,是严重影响癌症患者生存质量、疾病治疗及生存时间的综合征。目前临床研究,中药治疗癌症厌食恶病质综合征的各种经验方、成方等较少,且该类方剂无系统的组方规律研究,隐性规律不能被挖掘,使得临床用药难以创新性发现与认识。该文基于灰色理论并联合多元统计方法,分析中医治疗癌性纳差方剂的组方规律。通过自建"癌性纳差处方数据库",并从中筛选出359个处方进行分析,确定了处方中药物出现的频次,常用药对组合,并演化得到不同证型下的新处方4首。中医治疗癌性纳差的方剂以健脾益气为主,需注重以温补肾精、调理肝肺之气为辅,用药应考虑阴阳的互根互用,体现中医的整体观与辨证论治思想。以灰色关联分析、灰色聚类分析、因子分析等多元统计方法构成的灰色筛选法,可以实现对方剂组方规律的主客观分析,筛选出的基础新方,能为临床使用中药治疗癌性纳差和新药研发提供参考,是一个有价值的中医药研究辅助方法。Cancer-related anorexia syndrome（CACS） is one of the main causes for death at present as well as a syndrome seriously harming patients＇ quality of life,treatment effect and survival time. In current clinical researches,there are fewer reports about empirical traditional Chinese medicine（ TCM） prescriptions and patent prescriptions treating CACS,and prescription rules are rarely analyzed in a systematic manner. As the hidden rules are not excavated,it is hard to have an innovative discovery and knowledge of clinical medication. In this paper,the grey screening method combined with the multivariate statistical method was used to build the ″CACS prescriptions database″. Based on the database,totally 359 prescriptions were selected,the frequency of herbs in prescription was determined,and commonly combined drugs were evolved into 4 new prescriptions for different syndromes. Prescriptions of TCM in treatment of CACS gave priority to benefiting qi for strengthening spleen,also laid emphasis on replenishing kidney essence,dispersing stagnated liver-qi and dispersing lung-qi. Moreover,interdependence and mutual promotion of yin and yang should be taken into account to reflect TCM＇s holism and theory for treatment based on syndrome differentiation. The grey screening method,as a valuable traditional Chinese medicine research-supporting method,can be used to subjectively and objectively analyze prescription rules; and the new prescriptions can provide reference for the clinical use of TCM for treating CACS and the drug development.

关 键 词：癌性纳差 处方规律 灰色筛选 

分 类 号：R259[医药卫生—中西医结合]