中药注射剂超分子“印迹模板”特征对其(类)致敏性影响的探讨  

Impact of ″imprinting templates″ characteristics of traditional Chinese medicine injection supramolecules on( anaphylactoid) hypersensibility

作　　者：贺福元[1,2,3,4] 贺红[1,3] 周逸群[1,2,3] 邓凯文[5] 王志琪[1,2] 杨岩涛[1,2,4] 唐昱[1,2,4] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]中药药性与药效国家中医药管理局重点实验室,湖南长沙410208 [3]湖南中医药大学中药饮片与制剂超分子技术,湖南长沙410208 [4]湖南中医药大学中医药超分子机理与数理特征化实验室,湖南长沙410208 [5]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中国中药杂志》2016年第2期345-349,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81270055;81573691);国家博士点基金项目(20124323110002);湖南省自然科学基金项目(2015JJ2111);湖南省教育厅重点项目(14A108);湖南省教育厅十二五药学重点学科项目

摘　　要：阐明中药注射剂超分子"印迹模板"特征的(类)致敏性机制,为构筑其安全性评价方法奠定基础。在前文超分子化学对中医药理论特殊影响的基础上,进一步运用超分子"印迹模板"理论分析中药注射剂产生(类)致敏性自然本源,结合鱼腥草注射剂的(类)致敏现象,阐述中药注射剂中超分子"印迹模板"结构特征对其(类)致敏性的影响。中药注射剂可自主产生超分子结构,呈现整体表观(类)致敏性,强度决定其结构特征,存在(类)致敏临界超分子结构。"注射"给药其结构难被破坏,易呈表观免疫原性;而"口服"给药,其结构将被胃肠道破坏,表观免疫原性弱或消失",因此中药呈现"注射"与"口服"给药(类)致敏性的差异。中药注射剂"分子社会"间按"印迹模板"特征自主作用产生超分子,呈表观免疫应答,贯通识别、拷贝、贮存的免疫过程,单成分产生(类)致敏反应为其特例。中药注射剂(类)致敏原的筛查包括单成分及其形成的超分子,这是中药注射剂的安全性评价所特有的地方。The（anaphylactoid） hypersensibility mechanism of ″imprinting templates″ characteristics of traditional Chinese medicine（TCM） injection supramolecules was clarified to lay the foundation to build safety evaluation method. Based on the previous publication on special impact of Chinese medicine theories on supramolcular chemistry,combined with the natural origination of（ anaphylactoid）hypersensitized special rules as well as the sensitization phenomenon of cordate houttuynia injection,the impact of the structure characteristics of ″imprinting templates″ in TCM injection supramolecules on its（ anaphylactoid） hypersensibility was clarified. In Chinese medicine injections,the supramolecular structures can independently be generated,showing overall apparent（ anaphylactoid） hypersensibility nature,and their structure characteristics were dependent on the strength. In addition,（ anaphylactoid） hypersensitive critical supramolecular structure was present. When it was administrated by ″injection″,it＇ s structure was not easy to be destroyed,often showing apparent immunogenicity,whereas if it was administrated by ″oral″,the structure would be destroyed by the gastrointestinal tract,showing weaker or no apparent immunogenicity. Therefore,there are differences in（ anaphylactoid） hypersensibility between ″injection″ and ″oral″ administration of TCM. TCM injections would produce the supramolecules between ″molecular society″ by independent reaction of supramolecular ″imprinting template″（ chemical determinants）,showing apparent immune process of recognition,copying,and storage. Single molecule is a special example for this. The screening of anaphylactoid（ sensitinogen） includes the single ingredients and their forming supramolecules for TCM injection. This is the unique feature for safety evaluation of Chinese medicine injection.

关 键 词：中药注射剂 安全性 超分子药(毒)理学 超分子 印迹模板 分子社会 

分 类 号：R286[医药卫生—中药学]