假结核耶尔森氏菌与宿主之间相互作用的分子机制研究进展  

Advance in molecular mechanism of host-microbe: invasion and survival of Yersinia pseudotuberculosis in host cells

作　　者：黄睿[1] 马艳庆[1] 赵晋[1] 宋雷[1] 

机构地区：[1]西北民族大学医学院,甘肃兰州730030

出　　处：《微生物学通报》2016年第3期640-647,共8页Microbiology China

基　　金：中央高校基本科研业务费专项资金项目(No.31920150041)~~

摘　　要：耶尔森氏菌属中有3个种对人和动物具有致病性,包括鼠疫杆菌(Yersinia pestis)、小肠结肠炎耶尔森氏菌(Yersinia enterocolitica)和假结核耶尔森氏菌(Yersinia pseudotuberculosis)。研究发现,假结核耶尔森氏菌能通过小鼠小肠派氏淋巴结的M细胞(Microfold cell)进行跨细胞转运。这种转运方式首先是细菌利用其表面蛋白侵袭素Invasin或黏附素Yad A蛋白识别并结合宿主细胞表面的整合素Integrin受体家族成员的β1链,然后细胞膜上的分泌通道打开,细菌利用Ⅲ型分泌系统把效应蛋白注入宿主细胞内,破坏宿主细胞免疫系统进行感染的过程。过去三十年内关于假结核耶尔森氏菌有大量的文献报道,本文综述该菌与宿主细胞之间相互作用分子机制的研究进展,并讨论目前关于假结核耶尔森氏菌的研究方向及热点。Three Yersinia species are pathogenic to rodent and human, include Yersinia pestis, Y. enterocolitica and Y. pseudotuberculosis. Y. pseudotuberculosis can transport across microfold cell（M cell） distributed on the peyers patch of small intestine of mouse. They initially take advantage of the surface docks such as adhesins Yad A or invasin to interact with β1 chain of integrin receptors at the host cell surface. Then, Yops are exported by the type III secretion systems（TTSSs） when secretion channels open, and finally give rise to suppressed host immune response. Many studies about Y. pseudotuberculosis have been published over the past 30 years. Advances about molecular mechanism of interaction between Y. pseudotuberculosis and host cell have been reviewed here. Meanwhile, the focal point and developing trend about Y. pseudotuberculosis were also discussed.

关 键 词：假结核耶尔森氏菌 侵袭素 整合素 黏附素 Ⅲ型分泌系统 电子断层扫描技术 

分 类 号：R378[医药卫生—病原生物学]