参麦注射液对急性心肌梗死患者急诊PCI术后心肌的影响  

Influence of Shenmai Injection on Myocardia of Patients with Acute Myocardial Infarction After PCI Operation

作　　者：黎清华 邓行 周晓燕 姜惠敏 

机构地区：[1]宁乡县人民医院,湖南宁乡410600

出　　处：《河南中医》2016年第3期430-433,共4页Henan Traditional Chinese Medicine

基　　金：湖南省自然科学基金(编号:05JJ30175)

摘　　要：目的:观察参麦注射液对急性心肌梗死患者急诊PCI术后心肌的影响。方法:选取2012年6月—2014年6月本院收治的急性心肌梗死行急诊PCI手术的患者96例,按照随机数字表法分为研究组和对照组,每组48例。对照组术后予常规治疗,常规服用美托洛尔、单硝酸异山梨酯、氯沙坦钾、阿司匹林、氯吡格雷,研究组在对照组的基础上,术前即给予以参麦注射液加入生理盐水静脉滴注。观察两组患者治疗前后心功能评级、血液相关指标、超声心电图的变化和不良心血管事件发生率。结果:两组患者术后第1 d、第7 d BNP、CK-MB、c Tn I与术前比较均明显升高(P<0.05),观察组术后第1 d、第3 d、第7 d BNP、CK-MB和c Tn I水平均低于对照组(P<0.05);观察组术后第3 d、第7 d心功能Ⅰ级率明显高于对照组(P<0.05);观察组术后左心室舒张末内径、收缩末内径、射血分数改善程度优于对照组(P<0.05);观察组MACE发生率为8.33%,对照组MACE发生率为25.00%,观察组优于对照组(P<0.05)。结论:参麦注射液既可保护急性心肌梗死患者PCI术后的心肌细胞,减轻手术的不利影响,降低MACE的发生率。Objective： To observe the influence of Shenmai Injection on myocardia of patients with acute myocardial infarction（ AMI）. after PCI operation Methods： Totally 96 patients with AMI after PCI operation hospitalized between June 2012 and June2014 were randomly divided into research group and control group,with 48 cases in each group. Control group were given conventional treatment with drugs of metoprolol,isosorbide mononitrate,iosartan potassium,aspirin and clopidogrel while research group were additionally given intravenous drip of Shenmai Injection combined with normal saline. The grade of heart function,blood relevant indexes,changes of ultrasound cardiogram and occurrence rate of cardiovascular events in both groups before and after the treatment were observed. Results： The levels of BNP,CK-MB and c Tn I on the 1stand 7thday of the operation presented significant increase compared with these before the treatment（ P 〈 0. 05）. The levels of BNP,CK-MB and c Tn I in observation group on the1 st,3rdand 7thday were lower than these in control group（ P 〈 0. 05）. The rate of heart function level Ⅰ on the 3rdand 7thday in the observation group was apparently higher than that in control group（ P 〈 0. 05）. The improvements of left ventricular diastolic inner diameter,systolic inner diameter and ejection fraction in observation group were better than these in control group（ P 〈0. 05）. The occurrence rate of MACE was 8. 33% in observation group and 25. 00% in control group,with statistical significance（ P 〈 0. 05）. Conclusion： Shenmai Injection can not only protect the myocardial cells of patients with AMI after PCI operation,but also reduce the adverse influence of the operation and reduce the occurrence rate of MACE.

关 键 词：急性心肌梗死 经皮冠状动脉介入治疗 参麦注射液 

分 类 号：R259.422.2[医药卫生—中西医结合]