海藻酸钠纳米粒制备的研究进展  

Review on Preparation of Sodium Alginate Nanoparticles

作　　者：吴叶[1] 刘袖洞[1] 王云红[1] 于炜婷[2] 戴小敏[1] 马小军[2] 

机构地区：[1]大连大学环境与化学工程学院,大连116622 [2]中国科学院大连化学物理研究所,大连116023

出　　处：《材料导报》2016年第5期7-11,共5页Materials Reports

基　　金：国家自然科学基金(21276033);辽宁省"十百千高端人才引进工程"启动基金(辽人社[2012]207号);辽宁省高等学校优秀科技人才支持计划(LR2013057)

摘　　要：纳米粒药物载体能帮助药物靶向传输及可控释放,是生物医药领域的重要研究方向。海藻酸钠生物相容性好、易于修饰及加工形成微纳米颗粒,作为药物载体的应用研究日渐增多。综述了制备海藻酸钠纳米粒的4种方法,即离子交联法、乳化法、静电络合法和自组装法,并指出了4种方法的优缺点。Nanoparticle-based drug carriers can realize the targeted transportation and controlled release of drugs, so it is an important research direction in biomedical areas. In view of the biocompatibility, easily being modi- fied and processed to micro-/nano- particles, sodium alginate has been gradually used to prepare nanoparticles for drug loading. Four main methods to prepare sodium alginate nanoparticles are summarized, that is, ionic crosslinking, e- mulsion, electrostatic complexation and self-assembly, and the advantages and disadvantages of the four methods are introduced.

关 键 词：海藻酸钠 纳米粒 药物载体 

分 类 号：O636.9[理学—高分子化学]